Application of chemometric modelling to UV-Vis spectroscopy: development of simultaneous API and critical excipient assay in a liquid solution continuous flow
| Autor: | Saunier Josselin, Anamaria Angheluta, Samd Guizani, Robert Rönnback |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Chromatography Ultraviolet Rays Continuous flow Chemistry Pharmaceutical Spectrum Analysis Pharmaceutical Science Excipient 02 engineering and technology General Medicine 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy Excipients Solutions Chemometrics 03 medical and health sciences 0302 clinical medicine Ultraviolet visible spectroscopy Pharmaceutical Preparations Calibration medicine Technology Pharmaceutical 0210 nano-technology Spectroscopy medicine.drug |
| Zdroj: | Pharmaceutical Development and Technology. 25:919-929 |
| ISSN: | 1097-9867 1083-7450 |
| DOI: | 10.1080/10837450.2020.1770789 |
| Popis: | By applying Chemometric modelling to UV-Vis spectroscopy, a single Multi-Variate Data Analysis predictive model, for in-line monitoring of two component concentrations in solution formulation, was developed. The purpose of this article is to summarize the experimental development work performed for the UV-Vis analytical method and calibration modelling to determine the content of active pharmaceutical ingredient Carbetocin and the content of one critical excipient (l-methionine) in PABAL® solution for injection 100 µg/mL. |
| Databáze: | OpenAIRE |
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