Obstructive lung disease is common in children with syndromic and congenital scoliosis: a preliminary study
| Autor: | Peter Sturm, Richard Paul Boesch, Robert E. Wood, Eric J. Wall, Greg Redding, Barbara A. Chini, Viral Jain, Sacha A. Howells, Alvin H. Crawford, Steven S. Agabegi, Gary L. McPhail, Mathew Ednick |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty MEDLINE Scoliosis Thoracic Vertebrae Pulmonary function testing Bronchoscopy medicine Prevalence Humans Orthopedics and Sports Medicine Restrictive lung disease Lung Diseases Obstructive Child Retrospective Studies medicine.diagnostic_test business.industry Infant Magnetic resonance imaging Retrospective cohort study General Medicine respiratory system medicine.disease Magnetic Resonance Imaging Obstructive lung disease Respiratory Function Tests Child Preschool Pediatrics Perinatology and Child Health Female Radiology business Tomography X-Ray Computed |
| Zdroj: | Journal of pediatric orthopedics. 33(8) |
| ISSN: | 1539-2570 |
| Popis: | It is well known that restrictive lung disease (RLD) is associated with scoliosis. This study identifies that obstructive lung disease (OLD) is associated with syndromic scoliosis and congenital scoliosis.We searched a local database for patients with scoliosis who underwent a pulmonary function testing (PFT) from 2004 to 2009. All patients with congenital scoliosis or syndromic thoracolumbar scoliosis with a Cobb angle of ≥40 degrees and acceptable and repeatable PFT testing were included in the study. OLD was defined as an forced expiratory volume in the first second/forced vital capacity ratio below 95% confidence interval. Bronchoscopy videos and computed tomography scans or magnetic resonance images were reviewed to identify anatomic causes of lower airway disease.A total of 18 patients met the criteria for inclusion. The median age at diagnosis was 11.3 years. The median primary Cobb angle was 60 degrees. The prevalence of OLD was 33% and RLD was 57%. The 6 children with OLD underwent preoperative bronchoscopy and chest computed tomography or magnetic resonance imaging to identify anatomic causes of lower airway obstruction. The 4 children with OLD and right-sided major thoracic curves had compression of the right mainstem bronchus between the spine (posterior) and the right pulmonary artery (anterior). The 2 children with OLD and left-sided major thoracic curves had compression of the left mainstem bronchus between the spine (posterior) and the descending aorta (anterior) or the left atrium (anterior).In our study, the prevalence of OLD in children with congenital scoliosis or syndromic scoliosis was 33%, which was elevated when compared with the population prevalence of 2% to 5%. Mainstem airway compression from spine rotation was discovered to be the potential mechanism of disease.Level IV, prognostic study investigating the effect of a patient characteristic on the outcome of disease. |
| Databáze: | OpenAIRE |
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