Leucine-induced hypoglycemia
| Autor: | Victor H. Auerbach, Angelo M. DiGeorge, C. Charlton Mabry |
|---|---|
| Rok vydání: | 1960 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty business.industry Insulin medicine.medical_treatment Tryptophan Blood sugar Hypoglycemia medicine.disease Amino acid Endocrinology chemistry Blood chemistry Internal medicine Pediatrics Perinatology and Child Health medicine Leucine-induced hypoglycemia Tyrosine Leucine business |
| Zdroj: | The Journal of Pediatrics. 57:539-547 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(60)80081-9 |
| Popis: | Summary Two infants with leucine-sensitive hypoglycemia have been studied to elucidate the specificity and mechanism of action of l -leucine. Sixteen other naturally occurring l -amino acids have been administered intravenously and tyrosine and tryptophan by gavage. Of these amino acids, only l -leucine consistently induced hypoglycemia. d -leucine also produced hypoglycemia when given intravenously. Alpha-ketoisocaproic and isovaleric acids were administered intravenously; the former induced hypoglycemia whereas the latter did not. Monocarboxylic keto-acids in the urine were measured following l -leucine or alphaketoisocaproic acid loading. The recovery of keto-acids in the urine was of a low order, similar to that of a control subject indicating no metabolic defect in the conversion of alpha-ketoisocaproic acid to isovaleric acid. Preliminary evidence is presented that leucine administration to affected patients results in increased circulating insulin levels. |
| Databáze: | OpenAIRE |
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