Intravenous administration of haloperidol to healthy volunteers: lack of subjective effects but clear objective effects
| Autor: | N.A. Wellman, Philip J. Cowen, J. N. P. Rawlins, D P Geaney, J. Feldon, Jonathan H. Williams |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Visual analogue scale medicine.medical_treatment media_common.quotation_subject Blood Pressure Placebo behavioral disciplines and activities 03 medical and health sciences 0302 clinical medicine Double-Blind Method Heart Rate medicine Haloperidol Humans Attention Pharmacology (medical) Psychological testing 030212 general & internal medicine Saline media_common Pharmacology 030227 psychiatry Affect Psychiatry and Mental health Mood Feeling Anesthesia Injections Intravenous Female Psychology Antipsychotic Agents medicine.drug Vigilance (psychology) |
| Popis: | Healthy volunteers who received i.v. injections of either saline or haloperidol (0.5 or 1.0 mg) made visual analogue scale ratings of subjective mood, tension, shakiness and the global feeling of having received an active drug. The subjective ratings of volunteers who received haloperidol did not differ, overall, from those who received saline. In contrast, the drug caused clear objective changes in several psychological tests. I.v. administration of low doses of haloperidol may permit double-blind testing of the psychological actions of haloperidol in healthy volunteers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|