The effect of annatto on insulin binding properties in the dog
| Autor: | E. Y. St. A. Morrison, Dalip Ragoobirsingh, K. R. M. Russell |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Erythrocytes medicine.medical_treatment High-performance liquid chromatography Diabetes Mellitus Experimental Dogs Diabetes mellitus Internal medicine medicine Animals Hypoglycemic Agents Insulin Receptor Chromatography High Pressure Liquid Pancreatic hormone Pharmacology Glucose tolerance test biology medicine.diagnostic_test Plant Extracts business.industry Bixaceae Glucose Tolerance Test medicine.disease biology.organism_classification Receptor Insulin Disease Models Animal Insulin receptor Endocrinology Leukocytes Mononuclear biology.protein Female Chromatography Thin Layer business Phytotherapy |
| Zdroj: | Phytotherapy Research. 19:433-436 |
| ISSN: | 1099-1573 0951-418X |
| DOI: | 10.1002/ptr.1650 |
| Popis: | Various plants are used in Caribbean folklore for the treatment of a variety of illnesses including diabetes mellitus. Preliminary investigations of several crude plant extracts have indicated that the annatto (Bixa orellana), among others, does in fact exhibit hypoglycaemic properties. This present investigation sought to isolate the hypoglycaemic principle(s) from the crude extract and to determine the mechanism of action. Purification experiments employing thin layer chromatography (TLC) and high performance liquid chromatography (HPLC) resulted in an oil-soluble, partially purified annatto extract. The latter caused a decrease in blood glucose level of 5.62+/-0.13 (n=34) mmol/dL versus 6.31+/-0.12 (n=34) for the control (p |
| Databáze: | OpenAIRE |
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