Ultrasound-mediated drug delivery using liposomes modified with a thermosensitive polymer
| Autor: | Kazuaki Ninomiya, Nobuaki Shimizu, Hiroyuki Tashita, Shinya Kawabata |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
endocrine system
Acoustics and Ultrasonics Polymers Acrylic Resins Inorganic Chemistry chemistry.chemical_compound Drug Delivery Systems Thermosensitive polymer immune system diseases polycyclic compounds medicine Chemical Engineering (miscellaneous) Environmental Chemistry Humans Radiology Nuclear Medicine and imaging Doxorubicin Ultrasonics Viability assay Liposome Chromatography Chemistry business.industry Organic Chemistry Ultrasound Temperature virus diseases Biological Transport Hep G2 Cells Calcein Cancer cell Drug delivery Liposomes business medicine.drug |
| Zdroj: | Ultrasonics sonochemistry. 21(1) |
| ISSN: | 1873-2828 |
| Popis: | Ultrasound-mediated drug delivery was established using liposomes that were modified with the thermosensitive polymer (TSP) poly(NIPMAM-co-NIPAM), which sensitized the liposomes to high temperatures. TSP-modified liposomes (TSP liposomes) released encapsulated calcein under 1 MHz ultrasound irradiation at 0.5 W/cm(2) for 120 s as well as the case under incubation at 42 °C for 15 min. In addition, uptake of the drug released from TSP liposomes by cancer cells was enhanced by ultrasound irradiation. In a cell injury assay using doxorubicin (DOX)-loaded TSP liposomes and ultrasound irradiation, cell viability of HepG2 cells at 6 h after ultrasound irradiation (1 MHz, 0.5 W/cm(2) for 30 s) with DOX-loaded TSP liposomes (TSP/lipid ratio=1) was 60%, which was significantly lower than that of the control conditions such as DOX-loaded TSP liposomes alone and DOX-loaded intact liposomes under ultrasound irradiation. |
| Databáze: | OpenAIRE |
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