YY1 overexpression is associated with poor prognosis and metastasis-free survival in patients suffering osteosarcoma
| Autor: | Gaetano Apice, Teresa Infante, Anna De Chiara, Raffaele Rossiello, Flavio Fazioli, Licciana Zanella, Filomena de Nigris, Claudio Napoli, Gennaro Chiappetta, Gaetano De Rosa, Mario Monaco, Marco Alberghini, Francesco Cacciatore |
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| Přispěvatelé: | de Nigris, F, Zanella, L, Cacciatore, F, De Chiara, A, Fazioli, F, Chiappetta, G, Apice, G, Infante, T, Monaco, M, Rossiello, R, DE ROSA, Gaetano, Alberghini, M, Napoli, C., de NIGRIS, Filomena, Rossiello, Raffaele, De Rosa, G, Napoli, Claudio |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Cancer Research medicine.medical_treatment Bone Neoplasms lcsh:RC254-282 Disease-Free Survival Metastasis angiogenesis Surgical oncology Internal medicine medicine Genetics Humans Prospective Studies Stage (cooking) Prospective cohort study YY1 Transcription Factor Chemotherapy Analysis of Variance Osteosarcoma Proportional hazards model business.industry Histology Middle Aged medicine.disease Prognosis lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Immunohistochemistry Neoplasm Proteins Multivariate Analysis embryonic structures Cancer research Female business Research Article |
| Zdroj: | BMC Cancer, Vol 11, Iss 1, p 472 (2011) BMC Cancer |
| Popis: | Background The polycomb transcription factor Yin Yang 1 (YY1) overexpression can be causally implicated in experimental tumor growth and metastasization. To date, there is no clinical evidence of YY1 involvement in outcome of patients with osteosarcoma. Prognosis of osteosarcoma is still severe and only few patients survive beyond five years. We performed a prospective immunohistochemistry analysis to correlate YY1 immunostaining with metastatic development and survival in a selected homogeneous group of patients with osteosarcoma. Methods We studied 41 patients suffering from osteosarcoma (stage II-IVa). Multivariate analysis was performed using Cox proportional hazard regression to evaluate the correlation between YY1 expression and both metastasis development and mortality. Results YY1 protein is not usually present in normal bone; in contrast, a high number of patients (61%) showed a high score of YY1 positive cells (51-100%) and 39% had a low score (10-50% positive cells). No statistical difference was found in histology, anatomic sites, or response to chemotherapy between the two degrees of YY1 expression. Cox regression analysis demonstrated that the highest score of YY1 expression was predictive of both low metastasis-free survival (HR = 4.690, 95%CI = 1.079-20.396; p = 0.039) and poor overall survival (HR = 8.353, 95%CI = 1.863-37.451 p = 0.006) regardless of the effects of covariates such as age, gender, histology and chemonecrosis. Conclusion Overexpression of YY1 in primary site of osteosarcoma is associated with the occurrence of metastasis and poor clinical outcome. |
| Databáze: | OpenAIRE |
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