| Autor: |
Xianwei Sun, Praveen Chintakunta, Andrew Badachhape, Rohan Bhavane, David Yang, Zbigniew Starosolski, Huan-Jui Lee, Ketan Ghaghada, Peter Vekilov, Ananth Annapragada, Eric Tanifum |
| Rok vydání: |
2022 |
| DOI: |
10.26434/chemrxiv-2022-1gqnf-v2 |
| Popis: |
The first line of treatment for most solid tumors is surgical resection of the primary tumor with adequate negative margins. Incomplete resections with positive margins account for over 75% of local recurrences and the development of distant metastases. In cases of oral cavity squamous cell carcinoma (OSCC), the rate of successful tumor removal with adequate margins is just 15-26%. Advanced real-time imaging methods that improve detection of tumor margins can help improve success rates. Fluorescence imaging in the second near-infrared (NIR-II) window has the potential to revolutionize the field due to its superior imaging qualities, but NIR-II dyes with adequate in vivo performance and safety profiles are scarce. We report a novel high-performance organic molecule NIR-II fluorophore, XW-03-66 , with a fluorescence quantum yield (QY) of 6.0% in aqueous media. XW-03-66 self-assembles into nanoparticles (~80 nm) and has a systemic circulation half-life (t 1/2 ) of 11.3 h. In mouse models of HPV+ and HPV- OSCC, XW-03-66 outperformed indocyanine green (ICG), a clinically available NIR dye, and enabled intraoperative NIR-II image-guided resection of the tumor and adjacent draining lymph node with negative margins. In vitro and in vivo toxicity assessments revealed minimal safety concerns for in vivo applications. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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