Quercetin-3-O-β-d-glucuronide isolated from Polygonum aviculare inhibits cellular senescence in human primary cells
Autor: | Hyung Chul Choi, Jae-Ryong Kim, Suk Hwan Baek, So-Young Park, Hwa Young Kim, Hyo Hyun Yang, Jung Hee Cho, Kyoung Hwangbo, Jong-Keun Son, Ming Shan Zheng |
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Rok vydání: | 2014 |
Předmět: |
Senescence
Cell Survival medicine.medical_treatment Metabolite Biology Antioxidants Umbilical vein chemistry.chemical_compound Glucuronides Drug Discovery Human Umbilical Vein Endothelial Cells medicine Humans Cells Cultured Cellular Senescence Skin chemistry.chemical_classification Reactive oxygen species Molecular Structure Growth factor Osmolar Concentration Organic Chemistry Polygonum aviculare Plant Components Aerial beta-Galactosidase biology.organism_classification Medicine Korean Traditional In vitro Skin Aging Cell biology chemistry Biochemistry Ethnopharmacology Molecular Medicine Quercetin Endothelium Vascular Polygonum Reactive Oxygen Species |
Zdroj: | Archives of Pharmacal Research. 37:1219-1233 |
ISSN: | 1976-3786 0253-6269 |
DOI: | 10.1007/s12272-014-0344-2 |
Popis: | Cellular senescence is known to contribute to tissue aging, a variety of age-related diseases, tissue regeneration, and cancer. Therefore, aging intervention might be useful for prevention of aging as well as age-related disease. In this study, we investigated compounds from Polygonum aviculare to determine if they inhibited cellular senescence in human primary cells, human dermal fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs). Ten compounds from P. aviculare were purified and their inhibitory effects on adriamycin-induced cellular senescence were measured by observing senescence-associated β-galactosidase (SA-β-gal) activity and reactive oxygen species. Among them, compound 9 (quercetin-3-O-β-D-glucuronide) showed inhibitory effects against cellular senescence in HDFs and HUVECs treated with adriamycin. Additionally, compound 9 rescued replicative senescence in HDFs and HUVECs. These data imply that compound 9 represses cellular senescence in human primary cells and might be useful for the development of dietary supplements or cosmetics that ameliorate tissue aging or aging-associated diseases. |
Databáze: | OpenAIRE |
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