Quercetin-3-O-β-d-glucuronide isolated from Polygonum aviculare inhibits cellular senescence in human primary cells

Autor: Hyung Chul Choi, Jae-Ryong Kim, Suk Hwan Baek, So-Young Park, Hwa Young Kim, Hyo Hyun Yang, Jung Hee Cho, Kyoung Hwangbo, Jong-Keun Son, Ming Shan Zheng
Rok vydání: 2014
Předmět:
Zdroj: Archives of Pharmacal Research. 37:1219-1233
ISSN: 1976-3786
0253-6269
DOI: 10.1007/s12272-014-0344-2
Popis: Cellular senescence is known to contribute to tissue aging, a variety of age-related diseases, tissue regeneration, and cancer. Therefore, aging intervention might be useful for prevention of aging as well as age-related disease. In this study, we investigated compounds from Polygonum aviculare to determine if they inhibited cellular senescence in human primary cells, human dermal fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs). Ten compounds from P. aviculare were purified and their inhibitory effects on adriamycin-induced cellular senescence were measured by observing senescence-associated β-galactosidase (SA-β-gal) activity and reactive oxygen species. Among them, compound 9 (quercetin-3-O-β-D-glucuronide) showed inhibitory effects against cellular senescence in HDFs and HUVECs treated with adriamycin. Additionally, compound 9 rescued replicative senescence in HDFs and HUVECs. These data imply that compound 9 represses cellular senescence in human primary cells and might be useful for the development of dietary supplements or cosmetics that ameliorate tissue aging or aging-associated diseases.
Databáze: OpenAIRE