Idiopathic generalised epilepsies of adult onset: a reappraisal and literature review
| Autor: | Sara Varanda, José Pimentel, Fernando H. Lopes da Silva, Pedro Guimarães |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pediatrics
medicine.medical_specialty medicine.diagnostic_test business.industry Eeg abnormalities Brain Electroencephalography General Medicine medicine.disease Neurology Grand mal Normal brain MRI EEG Findings Humans Medicine Anticonvulsants Epilepsy Generalized Neurology (clinical) Age of Onset Age of onset Juvenile myoclonic epilepsy business Medical literature |
| Zdroj: | Epileptic Disorders. 20:169-177 |
| ISSN: | 1950-6945 1294-9361 |
| DOI: | 10.1684/epd.2018.0976 |
| Popis: | Idiopathic generalised epilepsies are characterised by widespread, symmetric, bilateral spike-and-wave discharges on EEG. Onset typically occurs in children and adolescents, but may also start in adulthood. These forms of adult onset constitute the focus of this review. A critical analysis of the medical literature was conducted through a narrative review search of PubMed and Medline databases. Cases of idiopathic generalised epilepsies with adult onset, in general, are not considered to be independent nosological entities. The "grand mal on awakening" seems to prevail among the idiopathic syndromes of adult onset. The EEG findings that question the diagnosis of late-onset idiopathic generalised epilepsies consist mainly of patterns interpreted as representing focal epileptiform activity. Normal brain MRI and typical EEG abnormalities are essential for diagnosis. For all cases with symptomatology of suspected adult-onset idiopathic generalised epilepsy, it is mandatory to exclude neurological conditions that may be associated with epileptic seizures which appear in this age group. A correct diagnosis of adult-onset idiopathic generalised epilepsy alleviates concern for a symptomatic origin, leading to appropriate antiepileptic treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text