Late malignant transformation of a benign giant-cell tumor of bone. A case report
| Autor: | Herman M. Kroon, R. O. Van Der Heul, Pancras C.W. Hogendoorn, Antonie H. M. Taminiau, R. J. B. Sakkers |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Pathology medicine.medical_specialty medicine.medical_treatment Bone Neoplasms Metaphysis Malignant transformation Medicine Humans Orthopedics and Sports Medicine Knee Tibia Giant Cell Tumor of Bone Histiocytoma Benign Fibrous business.industry General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Curettage Radiation therapy Radiography medicine.anatomical_structure Cell Transformation Neoplastic Epiphysis Disease Progression Surgery Sarcoma Radiology business Giant-cell tumor of bone |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0021-9355 |
| Popis: | Malignant giant-cell tumors of bone are very rare. These tumors usually present as de novo lesions or, several years after treatment with curettage combined with radiation therapy, as malignant transformation of a benign giant-cell tumor. However, malignant transformation without adjuvant radiation therapy has also been reported1,2,5,8-12,14,16. We present a well documented case of late progression of a giant-cell tumor of bone to a malignant fibrous histiocytoma. In September 1991, a forty-five-year-old man was seen because of pain on the medial side of the left knee, especially at night. Almost twenty years earlier, in March 1972, a benign osteolytic lesion, which had been radiographically and histologically consistent with a low-grade giant-cell tumor of bone (Figs. 1 and 2), had been removed with curettage from the medial portion of the epiphysis and metaphysis of the proximal aspect of the left tibia. The defect had been filled with bone taken from the left iliac crest. No radiation therapy had been given. Follow-up radiographs made in 1980 had demonstrated sclerosis at the original site of the tumor as a result of the bone-grafting. No signs of recurrent tumor had been noted. Postoperatively, the patient had been pain-free until August 1991. Radiographs made in September 1991 showed no signs of local recurrence. Fig. 1 Anteroposterior radiograph of the left knee, made in March 1972, showing the original tumor. The osteolytic lesion is well demarcated on the medial side of the epiphysis and metaphysis of the proximal aspect of the tibia. There is endosteal thinning and some expansion of the bone. The radiographic appearance is consistent with a diagnosis of giant-cell tumor. Fig. 2 Micrograph of a speciment of the curetted tumor, showing a proliferation of mononuclear epithelioid cells with only slight … |
| Databáze: | OpenAIRE |
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