| Autor: |
Sihan Lv, Tingting Hu, Ru Zhang, Yue Zhou, Wenjing Yu, Zelin Wang, Changjie Shi, Junjiang Lian, Shichao Huang, Gang Pei, Bing Luan |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Diabetes. 72:326-335 |
| ISSN: |
0012-1797 |
| DOI: |
10.2337/db22-0552 |
| Popis: |
The imbalance between energy intake and energy expenditure leads to the prevalence of obesity world-widely. Strategy to simultaneously limit energy intake and promote energy expenditure will serve as a powerful mean for new obesity treatment. Here, we identified Rhamnose as a non-nutritive sweetener to promote adipose thermogenesis and energy expenditure. Rhamnose promotes cAMP production and PKA activation through dopamine receptor D1 in adipose tissue. As a result, Rhamnose administration promotes UCP1dependent thermogenesis and ameliorates obesity in mice. Thus, we have demonstrated a Rhamnose-dopamine receptor D1-PKA axis critical for thermogenesis and Rhamnose may serve as a new therapeutic molecular diet against obesity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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