Clinical Research on Prognostic Evaluation of Subjects With IPF by Peripheral Blood Biomarkers, Quantitative Imaging Characteristics and Pulmonary Function Parameters
| Autor: | Yan Yang, Feng Liu, Lu Guo, Caiyu Jiang, Hong Pu, Weimin Li, Yang Yang, Zhendong Zhong |
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| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry medicine.medical_specialty Vital capacity Gastroenterology Pulmonary function testing 03 medical and health sciences FEV1/FVC ratio Idiopathic pulmonary fibrosis 0302 clinical medicine DLCO Internal medicine medicine Humans Lung volumes Lung medicine.diagnostic_test business.industry Interstitial lung disease General Medicine respiratory system Prognosis medicine.disease Idiopathic Pulmonary Fibrosis respiratory tract diseases 030228 respiratory system Lung Diseases Interstitial business Biomarkers |
| Zdroj: | Archivos de Bronconeumología (English Edition). 56:365-372 |
| ISSN: | 1579-2129 |
| Popis: | Introduction Idiopathic pulmonary fibrosis (IPF) is an irreversible and progressive fatal interstitial lung disease with a poor prognosis. The aim of this study is to investigate the predictive value of combined blood biomarkers, pulmonary function and quantitative monitoring by computer-aided diagnosis (CAD) system in IPF patients. Methods Pulmonary baseline function and pathological features of 126 patients with IPF were analyzed using spirometry and chest X-ray. Patients were divided into survival group and non-survival group after 5 years follow-up. The relationships the levels of peripheral blood biomarkers, quantitative imaging characteristics and pulmonary function were analyzed between the two groups. Results The baseline level of serum Krebs von den Lungen-6 (KL-6) and C-X-C motif chemokine 13 (CXCL13) were moderately or highly correlated with annual changes in forced vital capacity (FVC), carbon monoxide diffusing capacity (DLCO), total lung capacity (TLC), total interstitial lung disease (ILD) lesions, and the volume changes of reticular. The baseline level of serum KL-6 was higher than the cut-off value of 800.0 U/ml and baseline level of serum CXCL13 was higher than the cut-off value of 62.0 pg/ml. IPF patients with baseline levels of serum KL-6 and CXCL13 lower than the cut-off value had longer median survival time. Conclusions Serum KL-6 and CXCL13 may be predictive biomarkers for the outcomes of patients with IPF patients and their baseline levels were related to the progression of pulmonary function and quantitative monitoring by CAD system. |
| Databáze: | OpenAIRE |
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