Tendon‐like tether formation fortongue‐base advancement in an ovine model using a novel implant device intended for the surgical management of obstructive sleep apnoea
| Autor: | Jade Peres, Sharon Prince, Jos Hille, Neil H. Davies, Elena Hofmann, Deon Bezuidenhout, Rushdi Hendricks |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Materials science medicine.medical_treatment Biomedical Engineering Tongue Base Tendons Biomaterials 03 medical and health sciences Polydioxanone chemistry.chemical_compound 0302 clinical medicine Implants Experimental Tongue medicine Animals Continuous positive airway pressure 030304 developmental biology Sleep Apnea Obstructive 0303 health sciences Sheep Airway obstruction medicine.disease Tendon Surgery Disease Models Animal medicine.anatomical_structure 030228 respiratory system chemistry Female Implant Airway |
| Zdroj: | Journal of Biomedical Materials Research Part B: Applied Biomaterials. 109:1005-1016 |
| ISSN: | 1552-4981 1552-4973 |
| Popis: | Obstructive sleep apnoea (OSA) is a serious debilitating condition with significant morbidity and mortality affecting almost one billion adults globally. The current gold standard in the non-surgical management of airway collapse is continuous positive airway pressure (CPAP). However, non-compliance leads to a high abandon rate (27-46%). While there are multiple sites of airway obstruction during sleep, the tongue base is recognized as the key player in the pathogenesis of OSA. Poor outcomes of current tongue suspension devices are due to fracture, slippage or migration of devices. Three tongue tethering device groups, namely a polydioxanone/polyurethane combination (PDO + PU) treatment group, a PDO analytical control group, and a polypropylene (PP) descriptive control group, were implanted into 22 sheep (75-85 kg) in a two-phased study. After implant times of 8, 16, and 32 weeks, sheep were serially euthanized to allow for explantation of their tongues and chins. The PDO + PU devices remodeled during the 32-week implant period into a hybrid biological tendon-like tether through the process of gradual degradation of the PDO and collagen deposition as shown by electrophoresis, histology and mechanical testing. The control PDO device degraded completely after 32 weeks and the PP devices remained intact. The hybrid biological tendon-like tether exhibited a break-strength of 60 N, thus exceeding the maximum force to overcome upper airway collapse. |
| Databáze: | OpenAIRE |
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