Early surfactant and non-invasive ventilation versus intubation and surfactant: a propensity score-matched national study
| Autor: | Hallvard Reigstad, Karl Ove Hufthammer, Arild E Rønnestad, Claus Klingenberg, Hans Jørgen Stensvold, Trond Markestad |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | e001527 BMJ Paediatrics Open |
| ISSN: | 2399-9772 |
| Popis: | ObjectiveTo compare outcome after less invasive surfactant administration (LISA) and primary endotracheal intubation (non-LISA) in infants born before gestational age (GA) 28 weeks.SettingAll neonatal intensive care units (NICUs) in Norway during 2012–2018.MethodsDefined population-based data were prospectively entered into a national registry. We compared LISA infants with all non-LISA infants and with non-LISA infants who received surfactant following intubation. We used propensity score (PS) matching to identify non-LISA infants who were similar regarding potential confounders.Main outcome variablesRate and duration of mechanical ventilation (MV), survival, neurological and gastrointestinal morbidity, and need of supplemental oxygen or positive pressure respiratory support at postmenstrual age (PMA) 36 and 40 weeks.ResultsWe restricted analyses to GA 25–27 weeks (n=843, 26% LISA) because LISA was rarely used at lower GAs. There was no significant association between NICUs regarding proportions treated with LISA and proportions receiving MV. In the PS-matched datasets, fewer LISA infants received MV (61% vs 78%, pConclusionLISA reduced the rate and duration of MV but had no other clear benefits. |
| Databáze: | OpenAIRE |
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