Acyclic cucurbit[n]uril-type molecular containers bind neuromuscular blocking agents in vitro and reverse neuromuscular block in vivo
| Autor: | Ben Zhang, Lyle Isaacs, Ulrike Hoffmann, Da Ma, Martina Grosse Sundrup, Matthias Eikermann |
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| Rok vydání: | 2012 |
| Předmět: |
Bridged-Ring Compounds
Models Molecular Chemistry Stereochemistry Medizin Imidazoles Neuromuscular Junction macromolecular substances General Chemistry Neuromuscular Blocking Agents Catalysis In vitro Rats Kinetics Molecular recognition In vivo medicine Neuromuscular Blockade Animals Humans Spectrophotometry Ultraviolet Rocuronium Receptor medicine.drug |
| Zdroj: | Angewandte Chemie (International ed. in English). 51(45) |
| ISSN: | 1521-3773 |
| Popis: | Be my guest: two acyclic cucurbit[n]uril-type receptors that carry SO(3) (-) -groups bind tightly to several commonly used neuromuscular blocking agents, such as rocuronium, in aqueous solution as revealed by direct and competitive UV/Vis binding assays. One of these containers functions as a potent reversal agent for rocuronium-induced neuromuscular block in rats. |
| Databáze: | OpenAIRE |
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