ACE1 polymorphism and progression of SARS
| Autor: | Le Dang Ha, Jun Ohashi, Tadatoshi Kuratsuji, Ikumi Matsushita, Hideki Yanai, Hoang Thuy Long, Minako Hijikata, Tran Quy, Takehiko Sasazuki, Vo Van Ban, Teruo Kirikae, Akihiko Kawana, Satoru Itoyama, Naoto Keicho, Nguyen Chi Phi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Candidate gene
Pneumonia Viral Biophysics Biology Peptidyl-Dipeptidase A Severe Acute Respiratory Syndrome Biochemistry Article Hypoxemia medicine Genetic predisposition Humans Genetic Predisposition to Disease Genetic Testing Allele Polymorphism skin and connective tissue diseases Hypoxia Molecular Biology Genetic testing Lung Polymorphism Genetic medicine.diagnostic_test Respiratory distress fungi Angiotensin-converting enzyme Cell Biology body regions Association study medicine.anatomical_structure Vietnam Immunology biology.protein Disease Progression medicine.symptom Angiotensin converting enzyme |
| Zdroj: | Biochemical and Biophysical Research Communications |
| ISSN: | 1090-2104 0006-291X |
| Popis: | We have hypothesized that genetic predisposition influences the progression of SARS. Angiotensin converting enzyme (ACE1) insertion/deletion (I/D) polymorphism was previously reported to show association with the adult respiratory distress syndrome, which is also thought to play a key role in damaging the lung tissues in SARS cases. This time, the polymorphism was genotyped in 44 Vietnamese SARS cases, with 103 healthy controls who had had a contact with the SARS patients and 50 controls without any contact history. SARS cases were divided into either non-hypoxemic or hypoxemic groups. Despite the small sample size, the frequency of the D allele was significantly higher in the hypoxemic group than in the non-hypoxemic group (p = 0.013), whereas there was no significant difference between the SARS cases and controls, irrespective of a contact history. ACE1 might be one of the candidate genes that influence the progression of pneumonia in SARS. |
| Databáze: | OpenAIRE |
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