Differential Effects of Diuresis and Beta-Adrenoreceptor Blockade During Angiotensin-Converting Enzyme Inhibition in Patients with Severe Hypertension
| Autor: | Bernard B. Megaffin, Jodi L. Lipson, Jan I. M. Drayer, Michael A. Weber |
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| Rok vydání: | 1982 |
| Předmět: |
Adult
Male medicine.medical_specialty Captopril medicine.medical_treatment Adrenergic beta-Antagonists Angiotensin-Converting Enzyme Inhibitors Propranolol Hydrochlorothiazide Internal medicine medicine Humans Pharmacology (medical) Diuretics Pharmacology biology Chemistry Angiotensin-converting enzyme Middle Aged Hydralazine Blood pressure Mean blood pressure Endocrinology Hypertension biology.protein Drug Therapy Combination Female Diuretic medicine.drug |
| Zdroj: | The Journal of Clinical Pharmacology. 22:179-186 |
| ISSN: | 0091-2700 |
| DOI: | 10.1002/j.1552-4604.1982.tb02160.x |
| Popis: | The orally administered blocker of angiotensin-converting enzyme, captopril, was given to 16 patients with moderate to severe hypertension in whom blood pressure could not adequately be controlled by combination treatment with a vasodilator (hydralazine 200 mg daily), a beta-blocker (propranolol 320 mg daily), and a diuretic (hydrochlorothiazide 100 mg daily). Captopril (450 mg daily) alone maintained blood pressure at the same levels as during previous administration of the combination, although in the absence of the diuretic and the beta-blocker there were increases in body weight of 1.8 ± 0.5 (S.E.) kg (P |
| Databáze: | OpenAIRE |
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