Interaction and cross-talk between non-coding RNAs
| Autor: | Rajvir Dahiya, Yuichiro Tanaka, Mitsuho Imai-Sumida, Soichiro Yamamura |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
RNA Untranslated Interaction Computational biology Review Biology 03 medical and health sciences Cellular and Molecular Neuroscience Circular RNA microRNA Animals Humans Gene Regulatory Networks Small nucleolar RNA Molecular Biology Pharmacology Genetics Regulation of gene expression Competing endogenous RNA urogenital system Epistasis Genetic MicroRNA Cell Biology Non-coding RNA Long non-coding RNA RNA silencing 030104 developmental biology Gene Expression Regulation Molecular Medicine PIWI-interacting RNAs |
| Zdroj: | Cellular and Molecular Life Sciences |
| ISSN: | 1420-9071 |
| Popis: | Non-coding RNA (ncRNA) has been shown to regulate diverse cellular processes and functions through controlling gene expression. Long non-coding RNAs (lncRNAs) act as a competing endogenous RNAs (ceRNAs) where microRNAs (miRNAs) and lncRNAs regulate each other through their biding sites. Interactions of miRNAs and lncRNAs have been reported to trigger decay of the targeted lncRNAs and have important roles in target gene regulation. These interactions form complicated and intertwined networks. Certain lncRNAs encode miRNAs and small nucleolar RNAs (snoRNAs), and may regulate expression of these small RNAs as precursors. SnoRNAs have also been reported to be precursors for PIWI-interacting RNAs (piRNAs) and thus may regulate the piRNAs as a precursor. These miRNAs and piRNAs target messenger RNAs (mRNAs) and regulate gene expression. In this review, we will present and discuss these interactions, cross-talk, and co-regulation of ncRNAs and gene regulation due to these interactions. |
| Databáze: | OpenAIRE |
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