Immediate hypersensitivity to polyethylene glycols in unrelated products: when standardization in the nomenclature of the components of drugs, cosmetics, and food becomes necessary
Autor: | Francisco Marco de la Calle, Vicente Jover Cerdá, Joan Doménech Witek, Ramón Rodríguez Pacheco, María Luz de la Sen Fernández |
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Rok vydání: | 2019 |
Předmět: |
lcsh:Immunologic diseases. Allergy
Macrogol Allergy medicine.medical_specialty Polyethylene glycol Excipient allergy media_common.quotation_subject Basophil activation test Case Report macromolecular substances Cosmetics chemistry.chemical_compound medicine Hypersensitivity Anaphylaxis Basophil activation test Excipient allergy Hypersensitivity Polyethylene glycol Anaphylaxis media_common Active ingredient business.industry General Medicine medicine.disease Dermatology Basophil activation chemistry lcsh:RC581-607 business Type I hypersensitivity |
Zdroj: | ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante instname r-FISABIO. Repositorio Institucional de Producción Científica Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology Allergy, Asthma & Clinical Immunology, Vol 15, Iss 1, Pp 1-5 (2019) r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
ISSN: | 1710-1484 1710-1492 |
Popis: | BACKGROUND: Polyethylene glycols (PEGs) and their derivatives are non-ionic polymers of ethylene oxide commercially available with numerous synonyms, such as macrogol, oxyethylene polymer, and laureth-9. Although these polymers are usually safe, mild to life-threatening immediate-type hypersensitivity reactions have been reported. Nevertheless, awareness about their allergic potential is minimal due to the non-standardization of their nomenclature. CASE PRESENTATION: We present the case of a 29-years-old woman who developed several local and systemic type I hypersensitivity reactions including a severe anaphylactic reaction to different pharmacologic and cosmetic products whose excipients included PEG. Prick tests and basophil activation tests were performed to several pharmacological and cosmetic products, but only those containing PEGs and their derivatives were positive. The patient was diagnosed with immediate hypersensitivity IgE-mediated to PEGs and its derivatives. CONCLUSIONS: Standardization of the terminology used to describe the presence of PEGs in products would help patients to identify them clearly and unequivocally and thus avoid the development of hypersensitivity reactions. It is also recommended studying PEG allergy in reactions to products containing PEGs, once allergy to the active ingredients has been excluded and in reactions to multiple unrelated drugs.Clinical study protocol number PI2018/29 (registered on 24 September 2018). |
Databáze: | OpenAIRE |
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