Role of chlorophyllin as an in vivo anticlastogen: protection against gamma-radiation and chemical clastogens
| Autor: | P.C. Kesavan, Lakshmi Sarma, Suresh K. Abraham |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Cyclophosphamide Ratón Pharmacology Toxicology Mice Clastogen chemistry.chemical_compound In vivo Genetics medicine Animals Micronucleus Tests Chlorophyllides Chemistry Chlorophyllin Antimutagenic Agents Radiation Injuries Experimental medicine.anatomical_structure Gamma Rays Mutation Micronucleus test Bone marrow Antimutagen medicine.drug |
| Zdroj: | Mutation Research/Genetic Toxicology. 322:209-212 |
| ISSN: | 0165-1218 |
| DOI: | 10.1016/0165-1218(94)90008-6 |
| Popis: | Chlorophyllin was evaluated in the mouse bone marrow micronucleus test for its possible protective effects against chromosomal damage induced by gamma-radiation, cyclophosphamide, N-nitroso-N-ethylurea and urethane. Three doses of chlorophyllin (50, 100 and 200 mg/kg, b.w.) were orally administered to mice 2 h before exposure to the clastogens under investigation. The results obtained demonstrated that chlorophyllin can significantly reduce the incidence of micronucleated polychromatic erythrocytes induced by gamma-radiation (1.15 Gy) and all the three chemical clastogens. However with the exception of cyclophosphamide there was no indication of a dose response for the in vivo anticlastogenic effects of chlorophyllin. |
| Databáze: | OpenAIRE |
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