Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection

Autor:	Rachel E. Sutton, Rachel S. Nargi, Robert H. Carnahan, William B. Klimstra, Lauren E. Williamson, Elad Binshtein, Erica Armstrong, Theron Gilliland, Lauren M. Walker, Arthur S. Kim, James E. Crowe, Clarissa L Durie, Michael S. Diamond, Nurgun Kose, Pramod Kumar Yadav, Julie M. Fox, Melanie D. Ohi, Robin G. Bombardi
Rok vydání:	2020
Předmět:	Adult Encephalomyelitis Equine Models Molecular medicine.drug_class Eastern equine encephalitis virus Virulence Biology Monoclonal antibody medicine.disease_cause Antibodies Viral General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Epitopes Mice 0302 clinical medicine Protein Domains Neutralization Tests medicine Animals Humans Antigens Viral Aerosolization 030304 developmental biology Glycoproteins Aerosols 0303 health sciences Cryoelectron Microscopy Virion Antibodies Monoclonal Virus Internalization medicine.disease Virology Antibodies Neutralizing Recombinant Proteins Disease Models Animal Mutagenesis Monoclonal biology.protein Encephalitis Virus Eastern Equine Female Sindbis Virus Antibody 030217 neurology & neurosurgery Encephalitis Protein Binding
Zdroj:	Cell
ISSN:	1097-4172
Popis:	Eastern equine encephalitis virus (EEEV) is one of the most virulent viruses endemic to North America. No licensed vaccines or antiviral therapeutics are available to combat this infection, which has recently shown an increase in human cases. Here, we characterize human monoclonal antibodies (mAbs) isolated from a survivor of natural EEEV infection with potent (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04cdf9725e44b8e263a6a9da6a70f084 https://pubmed.ncbi.nlm.nih.gov/33301709 Zobrazit plný text záznamu