Matrix Metalloproteinase-9 rs17576 Gene Polymorphism and Behçet's Disease: Is There an Association?
| Autor: | Asmaa Kamal, Fatema T. Elgengehy, Mohamed Momtaz Abd Elaziz, Sherif M. Gamal, Nesreen Sobhy, Amira Medhat, Al Hussein M. El Dakrony |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Risk medicine.medical_specialty Immunology Gene Expression Behcet's disease Disease Biology Matrix metalloproteinase Gastroenterology Polymorphism Single Nucleotide DNA sequencing 03 medical and health sciences Gene Frequency Internal medicine Genotype medicine Humans Genetic Predisposition to Disease Allele Promoter Regions Genetic Polymerase Alleles Base Sequence Behcet Syndrome General Medicine Sequence Analysis DNA medicine.disease Molecular biology 030104 developmental biology Matrix Metalloproteinase 9 Case-Control Studies biology.protein Egypt Female Gene polymorphism Polymorphism Restriction Fragment Length |
| Zdroj: | Immunological investigations. 46(5) |
| ISSN: | 1532-4311 |
| Popis: | Clinical studies have reported a significant association between matrix metalloproteinases (MMP), particularly (MMP-9), and inflammatory diseases including Behçet's disease (BD).To study the relationship between MMP-9 rs17576 gene polymorphism and the development of BD, and its relation to disease activity among Egyptian patients.A total of 100 BD patients and 100 healthy control volunteers were genotyped for MMP-9 rs17576 polymorphism with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), followed by the confirmation of our results in random subgroups using direct DNA sequencing technique.The frequency of the GG genotype and G allele was significantly higher in BD patients as compared to the normal controls (p = 0.011, OR 8.61; p = 0.03, OR 1.65, respectively). There was no significant association between the MMP-9 rs17576 polymorphism and the clinical outcomes of BD.our study suggests a significant association of the MMP-9 rs17576 A/G polymorphism with increased risk of BD development in Egyptian patients. |
| Databáze: | OpenAIRE |
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