Human seroreactivity to gut microbiota antigens
| Autor: | Charles O. Elson, Peter J. Mannon, Maria C. Jenmalm, L. Wayne Duck, Thomas Abrahamsson, Bengt Björkstén, Göran Berg, Benjamin S. Christmann, Charles N. Bernstein |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Allergy Immunology chemical and pharmacologic phenomena Adaptive Immunity Gut flora digestive system Article Immunoglobulin G Microbiology Immune system Antigen Hypersensitivity medicine Humans Immunology and Allergy Child Antigens Bacterial biology Adaptive atopy allergy childhood IgG microarray microbiota bacterial antigens bacterial antibodies Gastrointestinal Microbiome Klinisk medicin Infant Newborn Infant biochemical phenomena metabolism and nutrition Microarray Analysis biology.organism_classification Acquired immune system medicine.disease Intestines stomatognathic diseases Child Preschool biology.protein bacteria Female Bacterial antigen Clinical Medicine |
| Zdroj: | Journal of Allergy and Clinical Immunology. 136:1378-1386.e5 |
| ISSN: | 0091-6749 |
| Popis: | Background: Although immune responses directed against antigens from the intestinal microbiota are observed in certain diseases, the normal human adaptive immune response to intestinal microbiota is poorly defined. Objective: Our goal was to assess the adaptive immune response to the intestinal microbiota present in 143 healthy adults and compare this response with the response observed in 52 children and their mothers at risk of having allergic disease. Methods: Human serum was collected from adults and children followed from birth to 7 years of age, and the serum IgG response to a panel of intestinal microbiota antigens was assessed by using a novel protein microarray. Results: Nearly every subject tested, regardless of health status, had serum IgG that recognized a common set of antigens. Seroreactivity to the panel of antigens was significantly lower in atopic adults. Healthy infants expressed the highest level of IgG seroreactivity to intestinal microbiota antigens. This adaptive response developed between 6 and 12 months of age and peaked around 2 years of age. Low IgG responses to certain clusters of microbiota antigens during infancy were associated with allergy development during childhood. Conclusions: There is an observed perturbation of the adaptive response to antigens from the microbiota in allergic subjects. These perturbations are observable even in childhood, suggesting that optimal stimulation of the adaptive immune system by the microbiota might be needed to prevent certain immune-mediated diseases. Funding Agencies|National Institutes of Health [DK071176]; Swedish Research Council [K2011-56X-21854-01-06]; Swedish Heart-Lung Foundation [20050514]; Ekhaga Foundation [210-53]; Research Council for the South-East Sweden; Olle Engqvist Foundation; Swedish Asthma and Allergy Association; Vardal Foundation for Health Care Science and Allergy Research, Sweden [B2007 042]; University Hospital of Linkoping, Sweden |
| Databáze: | OpenAIRE |
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