Oromucosal films: from patient centricity to production by printing techniques

Autor: Mine Orlu, Jörg Breitkreutz, Niklas Sandler, Erica Sjöholm, Mariagiovanna Scarpa, Dina Kottke, J. Carolina Visser, Yu Tian, Henderik W. Frijlink, Wouter L. J. Hinrichs, Olga Kiefer, Herman J. Woerdenbag, Heidi Öblom
Rok vydání: 2019
Předmět:
systemic drug delivery
Local drug delivery
Computer science
mucoadhesive buccal films
Herbal extracts
CRITICAL MATERIAL ATTRIBUTES
Target groups
Pharmaceutical Science
3D printing
Nanotechnology
02 engineering and technology
Oral Mucosal Absorption
030226 pharmacology & pharmacy
IN-VITRO EVALUATION
Dosage form
03 medical and health sciences
Drug Delivery Systems
0302 clinical medicine
patient centricity
BUCCOADHESIVE FILM
Mucoadhesion
Animals
Humans
Patient centricity
FORMULATION
ORAL DOSAGE FORMS
Active ingredient
VIVO EVALUATION
ORODISPERSIBLE FILMS
business.industry
oromucosal films
Mouth Mucosa
Administration
Buccal
Patient Preference
Buccal administration
021001 nanoscience & nanotechnology
DRUG NANOPARTICLES
printing techniques
Printing
Three-Dimensional
DELIVERY-SYSTEM
0210 nano-technology
business
Zdroj: Expert Opinion on Drug Delivery. 16:981-993
ISSN: 1744-7593
1742-5247
DOI: 10.1080/17425247.2019.1652595
Popis: Introduction: Oromucosal films, comprising mucoadhesive buccal films (MBFs) and orodispersible films (ODFs), are considered patient-centric dosage forms. Target groups are patients with special needs. Various active pharmaceutical ingredients have been shown to be suitable for oromucosal film production. A shift is seen in the production techniques, from conventional solvent casting to printing techniques. Areas covered: In this review, the patient acceptability of oromucosal films is discussed. An overview is given of the small molecule drugs, biopharmaceuticals and herbal extracts that have been incorporated so far. Finally, the current state of 2D and 3D printing techniques for production purposes is discussed. Expert opinion: The patient-centric features are important for the further development and acceptance of this oral solid dosage form. Oromucosal films perfectly fit in the current attention for personalized medicine. Both MBFs and ODFs are intended for either a local or a systemic effect. For buccal absorption, sufficient mucoadhesion is one of the most important criteria an oromucosal film must comply with. For the preparation, the solvent casting technique is still predominately used. Some limitations of this production method can be tackled by printing techniques. However, these novel techniques introduce new requirements, yet to be set, for oromucosal film preparation.
Databáze: OpenAIRE
Externí odkaz: