PET/MRI assessment of lung nodules in primary abdominal malignancies : Sensitivity and outcome analysis
| Autor: | Mark Vangel, Pierpaolo Biondetti, Subba R. Digumarthy, Rita Maria Lahoud, Felipe S. Furtado, Umar Mahmood, Lale Umutlu, Bruce R. Rosen, Eric W. Zhang, Lina Garcia Cañamaque, David Groshar, Onofrio A. Catalano, Jo-Anne O. Shepard |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Nodule detection
Lung Neoplasms Outcome analysis Medizin Malignancy Sensitivity and Specificity 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography medicine Humans Radiology Nuclear Medicine and imaging In patient Lung Retrospective Studies PET-CT business.industry Advanced stage Nodule (medicine) General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Abdominal Neoplasms 030220 oncology & carcinogenesis medicine.symptom Tomography X-Ray Computed business Nuclear medicine |
| Popis: | To evaluate PET/MR lung nodule detection compared to PET/CT or CT, to determine growth of nodules missed by PET/MR, and to investigate the impact of missed nodules on clinical management in primary abdominal malignancies.This retrospective IRB-approved study included [18F]-FDG PET/MR in 126 patients. All had standard of care chest imaging (SCI) with diagnostic chest CT or PET/CT within 6 weeks of PET/MR that served as standard of reference. Two radiologists assessed lung nodules (size, location, consistency, position, and [18F]-FDG avidity) on SCI and PET/MR. A side-by-side analysis of nodules on SCI and PET/MR was performed. The nodules missed on PET/MR were assessed on follow-up SCI to ascertain their growth (≥ 2 mm); their impact on management was also investigated.A total of 505 nodules (mean 4 mm, range 1-23 mm) were detected by SCI in 89/126 patients (66M:60F, mean age 60 years). PET/MR detected 61 nodules for a sensitivity of 28.1% for patient and 12.1% for nodule, with higher sensitivity for 7 mm nodules ( 30% and 70% respectively, p 0.05). 75/337 (22.3%) of the nodules missed on PET/MR (follow-up mean 736 days) demonstrated growth. In patients positive for nodules at SCI and negative at PET/MR, missed nodules did not influence patients' management.Sensitivity of lung nodule detection on PET/MR is affected by nodule size and is lower than SCI. 22.3% of missed nodules increased on follow-up likely representing metastases. Although this did not impact clinical management in study group with primary abdominal malignancy, largely composed of extra-thoracic advanced stage cancers, with possible different implications in patients without extra-thoracic spread. |
| Databáze: | OpenAIRE |
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