Impairment of reactivity to lepromin by mycobacterial antigens related to, or identical with, Mycobacterium leprae
| Autor: | Emilia Tavares Simao, J. B. G. Kwapinski, N. Haddad, L. M. Bechelli |
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| Rok vydání: | 1975 |
| Předmět: |
Male
Immunology Bacillus Biology Applied Microbiology and Biotechnology Microbiology Antigen Genetics medicine Humans Hypersensitivity Delayed Molecular Biology Mycobacterium leprae Lepromin Skin Tests Antigens Bacterial Immunity Cellular Vaccination Infant General Medicine medicine.disease biology.organism_classification Cell mediated immunity Mycobacterial antigen Child Preschool BCG Vaccine Female Leprosy Brazil |
| Zdroj: | Canadian Journal of Microbiology. 21:896-901 |
| ISSN: | 1480-3275 0008-4166 |
| DOI: | 10.1139/m75-132 |
| Popis: | Three hundred and twenty young children were injected with Bacillus Calmette–Guérin (BCG) saline, or with one of the mycobacterial cytoplasmic antigens related with Mycobacterium leprae. At an appropriate time thereafter they were tested for dermal hypersensitivity to the antigens and for reactions to lepromin.Whereas all the antigens induced cell-mediated immunity, the incidence and intensity of late response to lepromin were significantly reduced in children preinjected with the cytoplasmic mycobacterial antigens, as contrasted with increased lepromin reactivity in the BCG group and with the findings in saline-injected children. |
| Databáze: | OpenAIRE |
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