Anti-TNF- therapy for renal amyloid as a complication of Crohn's disease
| Autor: | Christopher Bellamy, V Save, James P. Blackmur, F A Chapman, C Whitworth, N Dhaun, J N Plevris, A G Shand |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Gastroenterology chemistry.chemical_compound Crohn Disease Internal medicine medicine Humans Outpatient clinic Serum amyloid A Creatinine Kidney Proteinuria biology Tumor Necrosis Factor-alpha business.industry Amyloidosis Anti-Inflammatory Agents Non-Steroidal Antibodies Monoclonal Angiotensin-converting enzyme General Medicine medicine.disease Infliximab medicine.anatomical_structure chemistry biology.protein Drug Therapy Combination Kidney Diseases medicine.symptom business Nephrotic syndrome |
| Zdroj: | QJM. 107:57-59 |
| ISSN: | 1460-2393 1460-2725 |
| DOI: | 10.1093/qjmed/hct112 |
| Popis: | Learning Point for Clinicians Renal amyloid is a rare complication of Crohn’s disease (CD). Increased mortality is associated with increased serum amyloid A (SAA) protein concentration and reducing SAA improves survival. Anti-TNF-α may treat both renal amyloid and CD. NSAID use may precipitate a CD flare. Collagenous colitis is associated with CD and amyloidosis. A 35-year-old butcher was admitted from the renal outpatient clinic for investigation and management of worsening peripheral oedema. He gave a past history of Crohn’s disease (CD). This had been asymptomatic for many months and so the patient had weaned himself of immunosuppression (azathioprine) 4 months earlier. On admission, serum albumin was |
| Databáze: | OpenAIRE |
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