Acute lethal and sublethal effects of diltiazem and doxepin for four aquatic environmental bioindicators covering the trophic chain
| Autor: | Estefanía Zuriaga, sup> Pilar Ribate, Cristina Belén García, Natalia Ros, Laura Lomba, Beatriz Giner |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Daphnia magna
Evaluación del impacto ambiental environmental risk assessment 02 engineering and technology Selenastrum 010501 environmental sciences 01 natural sciences Diltiazem medicine Ecotoxicity lcsh:Environmental sciences 0105 earth and related environmental sciences General Environmental Science EC50 lcsh:GE1-350 biology ecotoxicity Chemistry fungi doxepin diltiazem 021001 nanoscience & nanotechnology biology.organism_classification Doxepin Environmental risk assessment Bioavailability Environmental chemistry Toxicity Medio ambiente 0210 nano-technology Bioindicator medicine.drug |
| Zdroj: | R-USJ: Repositorio Institucional de la Universidad San Jorge Universidad San Jorge (USJ) AIMS Environmental Science, Vol 5, Iss 4, Pp 229-243 (2018) |
| Popis: | Pharmaceuticals are becoming an environmental and health problem of concern. We present here the results obtained in the ecotoxicological evaluation of two drugs (diltiazem and doxepin) recurrently present in the environment. To carry out this study, four aquatic bioindicators (Vibrio fischeri, Daphnia magna, Selenastrum capricornutum, and Danio rerio) were used and the lethal, sublethal and/or inhibition effects were obtained. Furthermore, in order to complete environmental information, several key physicochemical properties were also measured (solubility, critical aggregation concentration and partition coefficient). High solubility for doxepin seems to be related with its bioavailability and thus, lead to higher toxicity. However, EC50 ecotoxocity values for doxepin and diltiazem are between 100 and 1000 mg/L for all the studied environmental bioindicators, and thus, none of the drugs should be considered as potentially harmful for the environment. |
| Databáze: | OpenAIRE |
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