Regioselective C–H Amidation of (Alkyl)arenes by Iron(II) Catalysis
| Autor: | Shuai-Xin Fan, Shen-Yuan Zhang, Teck-Peng Loh, Yao Ding, Yu-Chen Chen, Jie-Sheng Tian |
|---|---|
| Přispěvatelé: | School of Physical and Mathematical Sciences |
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Sulfonyl 010405 organic chemistry Chemistry Organic Chemistry Regioselectivity Substrate (chemistry) 010402 general chemistry Ring (chemistry) 01 natural sciences Biochemistry Medicinal chemistry Natural-products 0104 chemical sciences Catalysis Chemistry [Science] N Bond Formation Physical and Theoretical Chemistry Nitrogen source Alkyl |
| Zdroj: | Organic Letters. 21:2736-2739 |
| ISSN: | 1523-7052 1523-7060 2017-1463 |
| DOI: | 10.1021/acs.orglett.9b00697 |
| Popis: | A nondirected amidation reaction of aromatic C-H bond was developed under iron(II) catalysis, using sulfonyl azides as the nitrogen source. The reaction displayed a broad substrate scope and good regioselectivities in the aspects of aromatic ring vs alkyl chain and different aromatic position of (alkyl)arenes. This method provided a new protocol for the synthesis of some aromatic amines, which were hard to achieve in a previous report. Nanyang Technological University We gratefully acknowledge Nanjing Tech University, Natural Science Foundation of Jiangsu Province (BK20171463), the State Key Program of National Natural Science Foundation of China (21432009), students’ project of Nanjing Tech University for innovation and entrepreneurship training program (2019DC0428), SICAM Fellowship and Scholarship by Jiangsu National Synergetic Innovation Center for Advanced Materials, and Nanyang Technological University for the generous financial support. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|