Patients with both Langerhans cell histiocytosis and Crohn’s disease highlight a common role of interleukin‐23
| Autor: | Martin Jädersten, Egle Kvedaraite, Jan-Inge Henter, Natalia Mouratidou, Jenée Mitchell, George Kannourakis, Fleur Cohen-Aubart, Yenan T. Bryceson, Magda Lourda, Selma Olsson Åkefeldt, Maja Ideström, George Z. Rassidakis, Tatiana von Bahr Greenwood, Julien Haroche, HongYa Han, Bianca Tesi, Mattias Svensson |
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| Přispěvatelé: | Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Institut E3M [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CIC Pitié BT, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP] |
| Rok vydání: | 2020 |
| Předmět: |
Immunology
Disease Interleukin-23 03 medical and health sciences 0302 clinical medicine Crohn Disease Langerhans cell histiocytosis 030225 pediatrics Interleukin 23 Humans Medicine In patient 030212 general & internal medicine [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics Crohn's disease business.industry Interleukin [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology Regular Article General Medicine medicine.disease 3. Good health interleukin‐23 Histiocytosis Langerhans-Cell Pediatrics Perinatology and Child Health Regular Articles & Brief Reports business |
| Zdroj: | Acta Paediatrica (Oslo, Norway : 1992) Acta Paediatrica Acta Paediatrica, Wiley, In press, ⟨10.1111/apa.15590⟩ |
| ISSN: | 1651-2227 0803-5253 |
| DOI: | 10.1111/apa.15590 |
| Popis: | International audience; Aim: To present the first case series of patients with Langerhans cell histiocytosis (LCH) also affected by Crohn's disease (CD), both of which are granulomatous diseases, and in LCH investigate the role of interleukin (IL)-23, which is a well-described disease mediator in CD.Methods: A case series of three patients with LCH and CD were described; a cohort of LCH patients (n = 55) as well as controls (n = 55) were analysed for circulating IL-23 levels; and the relation between the percentage of LCH cells in lesions and circulating IL-23 levels was analysed in seven LCH patients.Results: Differential diagnostic challenges for these two granulomatous diseases were highlighted in the case series, and it took up to 3 years to diagnose CD. Elevated IL-23 levels were found in LCH patients. The amount of lesional LCH cells correlated with the levels of circulating IL-23.Conclusion: Both CD and LCH should be considered in patients with inflammatory gastrointestinal involvement. The IL-23 pathway is a common immunological trait between these two granulomatous diseases. |
| Databáze: | OpenAIRE |
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