Maternal Anxiety and Depression during Late Pregnancy and Newborn Brain White Matter Development
| Autor: | Charles M. Glasier, Raghu H. Ramakrishnaiah, R.M. Graham, B.J. Bellando, Jessica L Coker, S.T. Sorensen, G. McCorkle, Xiawei Ou, L. Jiang, Amy C. Rowell |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Offspring Mothers Anxiety Pediatrics 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Child Development Pregnancy medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Prospective cohort study Depression (differential diagnoses) Obstetrics business.industry Depression Beck Depression Inventory Infant Newborn Brain Infant medicine.disease Mental health White Matter Diffusion Tensor Imaging Prenatal Exposure Delayed Effects Gestation Female Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | AJNR Am J Neuroradiol |
| ISSN: | 1936-959X |
| Popis: | BACKGROUND AND PURPOSE: Anxiety and depression during pregnancy have been associated with an increased risk of adverse neurodevelopmental outcomes in offspring. We aimed to study the in utero effects of maternal anxiety and depression on early brain development. MATERIALS AND METHODS: Pregnant women were recruited at ∼36 weeks of gestation for this prospective study. They were assessed for anxiety symptoms by the State-Trait Anxiety Inventory and for depression symptoms by the Beck Depression Inventory, 2nd Edition. After delivery, infant underwent an MR imaging examination of the brain without sedation, including DTI, for evaluation of white matter (WM) development. Infant fractional anisotropy values, a putative marker of WM integrity, were correlated with the mothers’ State-Trait Anxiety Inventory and Beck Depression Inventory scores by using both tract-based spatial statistics and ROI methods. RESULTS: Thirty-four infants were included in this study. Both maternal State-Anxiety and Trait-Anxiety scores negatively correlated (P |
| Databáze: | OpenAIRE |
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