Chemoprevention of colonic polyps with balsalazide: an exploratory, double-blind, placebo-controlled study
| Autor: | Young S. Kim, Vivian Weinberg, Kenneth R. McQuaid, Lorin K. Johnson, James R. Gum, Marvin H. Sleisenger, Jonathan P. Terdiman, Ann Hayes |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Physiology Colorectal cancer Placebo-controlled study Apoptosis Gastroenterology chemistry.chemical_compound Medicine & Public Health Prospective Studies Mesalamine Cancer Gastrointestinal agent Aspirin Balsalazide Middle Aged Phenylhydrazines Colo-Rectal Cancer Oncology Transplant Surgery 6.1 Pharmaceuticals Colonic Neoplasms Original Article medicine.drug Adenoma medicine.medical_specialty Colon Clinical Trials and Supportive Activities Clinical Sciences Sigmoid 5-Aminosalicylic acid Colonic Polyps Chemoprevention Mesalazine Gastrointestinal Agents Double-Blind Method Colon Sigmoid Clinical Research Internal medicine Complementary and Integrative Health medicine Humans Colonic polyp 3.3 Nutrition and chemoprevention Aged Nutrition Hepatology Gastroenterology & Hepatology business.industry Prevention medicine.disease digestive system diseases Biochemistry general chemistry business Digestive Diseases Colonic adenoma |
| Zdroj: | Digestive diseases and sciences, vol 54, iss 11 Terdiman, Jonathan P.; Johnson, Lorin K.; Kim, Young S.; Sleisenger, Marvin H.; Gum, James R.; Hayes, Ann; et al.(2009). Chemoprevention of Colonic Polyps with Balsalazide: An Exploratory, Double-Blind, Placebo-Controlled Study. Digestive Diseases and Sciences, 54(11), pp 2488-2496. doi: 10.1007/s10620-009-0966-2. Retrieved from: http://www.escholarship.org/uc/item/2362017j Digestive Diseases and Sciences |
| Popis: | Backgroud A number of agents, including aspirin, nonsteroidal antiinflammatory drugs, cyclooxygenase-2 inhibitors, folic acid, calcium, and vitamins, have been evaluated for their potential in chemoprevention of sporadic colorectal adenomas or cancer. Preclinical data suggest that 5-aminosalicylates also may have a chemopreventive effect. Aim To investigate chemoprevention of colonic polyps with balsalazide, a 5-aminosalicylate prodrug. Methods In this randomized, double-blind, placebo-controlled study, adults diagnosed with small polyps in the rectosigmoid colon were treated with either balsalazide 3 g/d or placebo for 6 months. Follow-up lower endoscopy was performed, and all polyps were measured and analyzed histologically. The primary endpoint was reduction in mean size of the largest polyp per subject. Results Among 241 participants screened, 86 were randomized to treatment, with 75 subjects evaluable. Balsalazide 3 g/d (n = 38) did not significantly reduce the mean size of the largest colonic polyp or the number of polyps compared with placebo (n = 37). Although not significant, post-hoc analysis revealed that total adenoma burden per subject, calculated as the sum of the volumes of all adenomas in mm3, increased by 55% in the balsalazide group compared with 95% in the placebo group. Conclusions Although balsalazide did not have significant chemopreventive effects on established colonic polyps, these results can aid in designing future prospective studies. |
| Databáze: | OpenAIRE |
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