Antibiotic-producing symbionts dynamically transition between plant pathogenicity and insect-defensive mutualism
| Autor: | Paul Gaube, Christian Hertweck, Andre Rodrigues, Elisabeth Sitte, Laura V. Flórez, Kirstin Scherlach, Claudia Ross, Cornelia Hermes, Martin Kaltenpoth |
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| Přispěvatelé: | Max Planck Institute for Chemical Ecology, Johannes Gutenberg University, HKI, Universidade Estadual Paulista (Unesp), Friedrich Schiller University |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Burkholderia gladioli Antifungal Agents medicine.drug_class Science media_common.quotation_subject 030106 microbiology Antibiotics General Physics and Astronomy Zoology Pyrimidinones Insect Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound medicine Animals Symbiosis In Situ Hybridization Fluorescence media_common Toxoflavin Mutualism (biology) Herbivore Multidisciplinary biology Triazines fungi Fungi food and beverages General Chemistry biology.organism_classification Anti-Bacterial Agents Coleoptera Chemical ecology 030104 developmental biology chemistry Soybeans Bacteria |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Nature Communications Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017) |
| Popis: | Pathogenic and mutualistic bacteria associated with eukaryotic hosts often lack distinctive genomic features, suggesting regular transitions between these lifestyles. Here we present evidence supporting a dynamic transition from plant pathogenicity to insect-defensive mutualism in symbiotic Burkholderia gladioli bacteria. In a group of herbivorous beetles, these symbionts protect the vulnerable egg stage against detrimental microbes. The production of a blend of antibiotics by B. gladioli, including toxoflavin, caryoynencin and two new antimicrobial compounds, the macrolide lagriene and the isothiocyanate sinapigladioside, likely mediate this defensive role. In addition to vertical transmission, these insect symbionts can be exchanged via the host plant and retain the ability to initiate systemic plant infection at the expense of the plant's fitness. Our findings provide a paradigm for the transition between pathogenic and mutualistic lifestyles and shed light on the evolution and chemical ecology of this defensive mutualism. Observations of recent or dynamic transitions between parasitism and mutualism are scarce. Here, Flórez et al. provide evidence that Burkholderia gladioli bacteria can protect the eggs of herbivorous beetles by producing antimicrobial compounds, while retaining their ancestral ability to infect plants. |
| Databáze: | OpenAIRE |
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