Improving the transport of chemotherapeutic drugs across the blood–brain barrier
| Autor: | Iduna Fichtner, Reiner Zeisig, Andrea Orthmann |
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| Rok vydání: | 2011 |
| Předmět: |
Drug
media_common.quotation_subject Antineoplastic Agents Nanotechnology Context (language use) Blood–brain barrier Animals Humans Medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics media_common Drug Carriers Liposome Brain Neoplasms business.industry Biological Transport General Medicine Anticancer drug Drug concentration medicine.anatomical_structure Blood-Brain Barrier Liposomes Chemotherapeutic drugs Nanocarriers business |
| Zdroj: | Expert Review of Clinical Pharmacology. 4:477-490 |
| ISSN: | 1751-2441 1751-2433 |
| DOI: | 10.1586/ecp.11.26 |
| Popis: | The successful treatment of brain tumors or metastases in the brain is still hampered by the very efficient blood-brain barrier, which prevents the cerebral accumulation of a pharmacologically sufficient amount of a drug. Beside the possibility of disintegrating the functionality of this effective working barrier, a nanocarrier-mediated transport is presently an interesting and promising method to increase the drug concentration in the brain. Nanocarriers are small vesicles ( |
| Databáze: | OpenAIRE |
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