Transitions between neocortical seizure and non-seizure-like states and their association with presynaptic glutamate release
| Autor: | Yotin Chinvarun, Peter L. Carlen, Vanessa L. Breton, Jose Martin Del Campo, Suzie Dufour, Berj L. Bardakjian |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Patch-Clamp Techniques Postsynaptic Current Voltage clamp Glutamic Acid Neocortex Local field potential Synaptic Transmission lcsh:RC321-571 03 medical and health sciences Epilepsy Young Adult 0302 clinical medicine Seizures medicine Animals Humans Seizure-like events lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Chemistry Glutamate receptor Excitatory Postsynaptic Potentials Classification medicine.disease Seizure Electrophysiology Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Neurology Synapses Excitatory postsynaptic potential Female Prediction Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurobiology of Disease, Vol 146, Iss, Pp 105124-(2020) |
| ISSN: | 1095-953X |
| Popis: | The transition between seizure and non-seizure states in neocortical epileptic networks is governed by distinct underlying dynamical processes. Based on the gamma distribution of seizure and inter-seizure durations, over time, seizures are highly likely to self-terminate; whereas, inter-seizure durations have a low chance of transitioning back into a seizure state. Yet, the chance of a state transition could be formed by multiple overlapping, unknown synaptic mechanisms. To identify the relationship between the underlying synaptic mechanisms and the chance of seizure-state transitions, we analyzed the skewed histograms of seizure durations in human intracranial EEG and seizure-like events (SLEs) in local field potential activity from mouse neocortical slices, using an objective method for seizure state classification. While seizures and SLE durations were demonstrated to have a unimodal distribution (gamma distribution shape parameter >1), suggesting a high likelihood of terminating, inter-SLE intervals were shown to have an asymptotic exponential distribution (gamma distribution shape parameter |
| Databáze: | OpenAIRE |
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