Celecoxib Is Associated With Dystrophic Calcification and Aortic Valve Stenosis
| Autor: | W. David Merryman, Michael A. Raddatz, Camryn L. Johnson, Brian R. Lindman, Meghan A. Bowler |
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| Rok vydání: | 2019 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Aortic valve medicine.medical_specialty CN calcific nodule AS aortic stenosis 030204 cardiovascular system & hematology calcification 03 medical and health sciences 0302 clinical medicine Dystrophic calcification Internal medicine LEADING EDGE IN TRANSLATIONAL RESEARCH medicine heterocyclic compounds COX2 cyclooxygenase-2 skin and connective tissue diseases TGF transforming growth factor ANOVA analysis of variance celecoxib AVEC aortic valve endothelial cell business.industry AS - Aortic stenosis aortic stenosis EMR electronic medical record AVIC aortic valve interstitial cell CDH11 cadherin-11 medicine.disease aortic valve FDA Food and Drug Administration 3. Good health CAVD calcific aortic valve disease OR odds ratio Stenosis 030104 developmental biology medicine.anatomical_structure Aortic valve stenosis cardiovascular system Celecoxib Cardiology SMA smooth muscle actin lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business VUMC Vanderbilt University Medical Center Calcification medicine.drug |
| Zdroj: | JACC: Basic to Translational Science |
| ISSN: | 2452-302X |
| DOI: | 10.1016/j.jacbts.2018.12.003 |
| Popis: | Visual Abstract Highlights • Celecoxib use is associated with diagnosis of aortic stenosis in analysis of electronic medical records. • Celecoxib treatment increases dystrophic calcification of aortic valve interstitial cells in vitro. • Dimethyl celecoxib, which binds CDH11, prevents TGF-β1–mediated calcification of aortic valve interstitial cells in vitro. Summary Calcific aortic valve disease is a progressive fibrocalcific process that can only be treated with valve replacement. Cadherin-11 has recently been identified as a potential therapeutic target for calcific aortic valve disease. The already approved drug celecoxib, a cyclooxygenase-2 inhibitor, binds cadherin-11, and was investigated as a therapeutic against calcific aortic valve disease. Unexpectedly, celecoxib treatment led to hallmarks of myofibroblast activation and calcific nodule formation in vitro. Retrospective electronic medical record analysis of celecoxib, ibuprofen, and naproxen revealed a unique association of celecoxib use and aortic stenosis. |
| Databáze: | OpenAIRE |
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