Durvalumab after definitive chemoradiotherapy in locally advanced NSCLC: Data of the German EAP
Autor: | Wolfgang M. Brückl, Felix Steger, Jürgen Alt, M. Faehling, Philipp Schütt, Petra Hoffknecht, Anke Schlenska-Lange, Marlitt Horn, Daniel C. Christoph, Christian Schumann, Petros Christopoulos, Stephan Eisenmann |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Oncology
PD-L1 medicine.medical_specialty Durvalumab Survival medicine.medical_treatment Population Locally advanced lcsh:Computer applications to medicine. Medical informatics NSCLC 03 medical and health sciences Oligometastatic 0302 clinical medicine Internal medicine Checkpoint inhibitor medicine Stage (cooking) lcsh:Science (General) Lung cancer education Adverse effect 030304 developmental biology Data Article 0303 health sciences education.field_of_study Chemotherapy Multidisciplinary business.industry Real world medicine.disease lcsh:R858-859.7 business 030217 neurology & neurosurgery Chemoradiotherapy lcsh:Q1-390 Autoimmune |
Zdroj: | Data in Brief Data in Brief, Vol 34, Iss, Pp 106556-(2021) |
ISSN: | 2352-3409 |
Popis: | Following the PACIFIC trial, durvalumab has been approved by the European Medicines Agency (EMA) for consolidation of locally advanced PD-L1-positive NSCLC after chemoradiotherapy (CRT). Patients were treated with durvalumab in the EAP from 22.11.2017 to 15.10.2018 allowing analysis of its efficacy and safety. 211 patients were registered by 90 German centres. Data were collected retrospectively by questionnaire and queries. 56 centres reported data on 126 patients who actually received at least one cycle of durvalumab. In contrast to the PACIFIC-trial population, some patients with oligometastatic disease and a history of autoimmune disease are included in the EAP population. Information on PD-L1 status was obtained for 111 patients. Baseline data include age, gender, ECOG, stage (IASLC 8th ed.), and smoking history. Treatment data include mode of chemoradiotherapy, used chemotherapy agent, and duration of durvalumab therapy. Adverse evants were documented according to CTAEC 5.0. Data were analysed for progression-free survival (PFS), overall survival (OS), and adverse events (AE). The results were published in Lung Cancer [1]. |
Databáze: | OpenAIRE |
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