Isolation and antimicrobial evaluation of isomeric hydroxy ketones in leaf cuticular waxes ofAnnona squamosa
| Autor: | K. Shiva Shanker, Rachapudi B. N. Prasad, Bhamidipati V. S. K. Rao, K. Hara Kishore, Sanjit Kanjilal, Sunil Misra |
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| Rok vydání: | 2006 |
| Předmět: |
Antifungal
Antifungal Agents Magnetic Resonance Spectroscopy Stereochemistry medicine.drug_class Microbial Sensitivity Tests Plant Science Biochemistry Annona Gas Chromatography-Mass Spectrometry Analytical Chemistry Homologous series chemistry.chemical_compound Anti-Infective Agents Isomerism Drug Discovery medicine Organic chemistry Wax Bacteria biology Chemistry Natural compound Fungi General Medicine Annona squamosa Ketones biology.organism_classification Antimicrobial Hydrocarbons Anti-Bacterial Agents Culture Media Plant Leaves Complementary and alternative medicine Annonaceae Waxes visual_art visual_art.visual_art_medium Molecular Medicine Antibacterial activity Food Science |
| Zdroj: | Phytochemical Analysis. 18:7-12 |
| ISSN: | 1099-1565 0958-0344 |
| DOI: | 10.1002/pca.942 |
| Popis: | A novel natural compound, 11-hydroxy-16-hentriacontanone, has been isolated from the leaf cuticular wax of Annona squamosa along with its known isomer 10-hydroxy-16-hentriacontanone in a ratio of 67:33. This isomeric mixture of hydroxy ketones constituted together 16.5% of the total cuticular waxes. The new compound was characterised using spectral and chromatographic techniques. The major component was found to be 16-hentriacontanone (palmitone), which constituted up to 48% of the total cuticular wax, together with a homologous series of hydrocarbons, fatty aldehydes, fatty alcohols, fatty acids and sterols as minor components. The antimicrobial activity of the isomeric hydroxy ketones was tested against selected Gram-positive and Gram-negative bacterial strains, and also some selected fungal strains, and compared with palmitone. The antibacterial activity of palmitone was significantly higher than that of the isomeric hydroxy ketones, but their antifungal activities were comparable. Copyright © 2006 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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