Dietary intake of flavonoids and ventilatory function in european adults : a GA2LEN Study
| Autor: | Thibaut Van Zele, Grzegorz Brożek, Marek L. Kowalski, Claus Bachert, Carlos Loureiro, James Potts, Peter Burney, Barbara Rymarczyk, Thomas Keil, Tari Haahtela, Trine Thilsing, Vanessa Garcia-Larsen, Ana Todo Bom, Matti Ahlström, Paolo M. Matricardi, Ewa Nizankowska-Mogilnicka, Narjis Thawer, Christer Janson, Aedin Cassidy, Joanna Makowska, Kjell Torén, David Charles, Bertil Forsberg |
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| Přispěvatelé: | Commission of the European Communities, Department of Dermatology, Allergology and Venereology, Clinicum, HUS Inflammation Center |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Agriculture and Food Sciences Physiology medicine.disease_cause 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit pro-anthocyanidins Medicine and Health Sciences flavonoids lung function GA2LEN Lung function POPULATION education.field_of_study Nutrition and Dietetics medicine.diagnostic_test Dietary intake Follow up studies Ventilatory function ASSOCIATION respiratory system 3142 Public health care science environmental and occupational health 3. Good health LUNG-FUNCTION Näringslära DISEASES GA(2)LEN lcsh:Nutrition. Foods and food supply Spirometry Population lcsh:TX341-641 METABOLISM 03 medical and health sciences INFLAMMATION medicine education DECLINE 030109 nutrition & dietetics Nutrition assessment business.industry respiratory tract diseases MICE 3121 General medicine internal medicine and other clinical medicine ASTHMA 1111 Nutrition And Dietetics ANTHOCYANIN business Oxidative stress Food Science |
| Zdroj: | Nutrients, Vol 10, Iss 1, p 95 (2018) NUTRIENTS Nutrients; Volume 10; Issue 1; Pages: 95 |
| ISSN: | 2072-6643 |
| Popis: | Background: Flavonoids exert anti-inflammatory properties and modulate oxidative stress in vitro, suggesting a protective effect on lung function, but epidemiological studies examining this association are scarce. Methods: A stratified random sample was drawn from the GA2LEN screening survey, in which 55,000 adults aged 15 to 75 answered a questionnaire on respiratory symptoms. Post-bronchodilator spirometry was obtained from 2850 subjects. Forced vital capacity (FVC), the ratio between the forced exhaled volume in 1 second (FEV1) and FVC (FEV1/FVC), FVC below lower limit of normal (FVC < LLN), and FEV1/FVC < LLN were calculated. Intake of the six main subclasses of flavonoids was estimated using the GA2LEN Food Frequency Questionnaire. Adjusted associations between outcomes and each subclass of flavonoids were examined with multivariate regressions. Simes’ procedure was used to test for multiple comparisons. Results: A total of 2599 subjects had valid lung function and dietary data. A lower prevalence of FVC < LLN (airway restriction) was observed in those with higher total flavonoid (adjusted odds ratio (aOR), higher vs. lowest quintile intake 0.58; 95% Confidence Interval (CI) 0.36, 0.94), and pro-anthocyanidin intakes (aOR 0.47; 95% CI 0.27, 0.81). A higher FEV1/FVC was associated with higher intakes of total flavonoids and pro- anthocyanidins (adjusted correlation coefficient (a β-coeff 0.33; 0.10, 0.57 and a β-coeff 0.44; 95% CI 0.19, 0.69, respectively). After Simes’ procedure, the statistical significance of each of these associations was attenuated but remained below 0.05, with the exception of total flavonoids and airway restriction. Conclusions: This population-based study in European adults provides cross-sectional evidence of a positive association of total flavonoid intake and pro-anthocyanidins and ventilatory function, and a negative association with spirometric restriction in European adults. View Full-Text |
| Databáze: | OpenAIRE |
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