Predictive value of long-term changes of growth differentiation factor-15 over a 27-year-period for heart failure and death due to coronary heart disease
| Autor: | Peter Moritz Becher, Tanja Zeller, Nina Fluschnik, Dirk Westermann, Stefan Blankenberg, Francisco Ojeda, Christoph Sinning, Torben Jørgensen, Kari Kuulasmaa |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male lcsh:Medicine Coronary Disease Blood Pressure Cardiovascular Medicine 030204 cardiovascular system & hematology Biochemistry Vascular Medicine Endocrinology Elderly 0302 clinical medicine Interquartile range Risk Factors Medicine and Health Sciences Coronary Heart Disease Heart Failure/blood Prospective Studies lcsh:Science education.field_of_study Multidisciplinary biology Hazard ratio Middle Aged Prognosis 3. Good health C-Reactive Protein Cardiovascular Diseases Creatinine Cohort Cardiology Female Research Article Adult medicine.medical_specialty Growth Differentiation Factor 15 Endocrine Disorders Cystatin C/blood Population 03 medical and health sciences Coronary Disease/blood Internal medicine Growth Differentiation Factor 15/blood Diabetes Mellitus medicine Humans Cystatin C education Proportional Hazards Models Heart Failure Proportional hazards model business.industry C-Reactive Protein/metabolism lcsh:R Biology and Life Sciences medicine.disease Confidence interval 030104 developmental biology Age Groups Metabolic Disorders Heart failure People and Places biology.protein Population Groupings lcsh:Q business Biomarkers Biomarkers/blood |
| Zdroj: | Fluschnik, N, Ojeda, F, Zeller, T, Jørgensen, T, Kuulasmaa, K, Becher, P M, Sinning, C, Blankenberg, S & Westermann, D 2018, ' Predictive value of long-term changes of growth differentiation factor-15 over a 27-year-period for heart failure and death due to coronary heart disease ', PLOS ONE, vol. 13, no. 5, e0197497 . https://doi.org/10.1371/journal.pone.0197497 PLoS ONE, Vol 13, Iss 5, p e0197497 (2018) Fluschnik, N, Ojeda, F, Zeller, T, Jørgensen, T, Kuulasmaa, K, Becher, P M, Sinning, C, Blankenberg, S & Westermann, D 2018, ' Predictive value of long-term changes of growth differentiation factor-15 over a 27-year-period for heart failure and death due to coronary heart disease ', PLoS ONE, vol. 13, no. 5, e0197497 . https://doi.org/10.1371/journal.pone.0197497 PLoS ONE |
| DOI: | 10.1371/journal.pone.0197497 |
| Popis: | Background Growth differentiation factor-15 (GDF-15), Cystatin C and C-reactive protein (CRP) have been discussed as biomarkers for prediction of cardiac diseases. The aim of this study was to investigate the predictive value of single and repeated measurements of GDF-15 compared to Cystatin C and CRP for incidence of heart failure (HF) and death due to coronary heart disease (CHD) in the general population. Methods and results Levels of GDF-15, CRP and Cystatin C were determined in three repeated measurements collected 5 years apart in the DAN-MONICA (Danish-Multinational MONitoring of trends and determinants in Cardiovascular disease) cohort (participants at baseline n = 3785). Cox regression models adjusted for cardiovascular risk factors revealed significantly increased hazard ratios (HR) for GDF-15 for incident HF 1.36 (HR per interquartile range (IQR) increase, 95% confidence interval (CI): 1.16; 1.59) and for death from CHD 1.51 (HR per IQR increase, 95% CI: 1.31, 1.75) (both with p |
| Databáze: | OpenAIRE |
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