Interleukin-6 and Depressive Mood Symptoms: Mediators of the Association Between Childhood Abuse and Cognitive Performance in Middle-Aged Adults
| Autor: | Michael R. Irwin, Ellen WanHeung Yeung, Kathryn Lemery-Chalfant, Alex J. Zautra, Linda J. Luecken, Mary C. Davis |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Aging Psychological intervention Blood Pressure Medical and Health Sciences 0302 clinical medicine Risk Factors Surveys and Questionnaires Medicine 2.1 Biological and endogenous factors 030212 general & internal medicine Metabolic risk Cognitive decline Aetiology General Psychology Depression (differential diagnoses) Pediatric education.field_of_study Depression Adult Survivors of Child Abuse Childhood abuse Cognition Middle Aged Mental Status and Dementia Tests Psychiatry and Mental health Mental Health Female Cognitive function Public Health Waist Circumference social and economic factors 0305 other medical science Clinical psychology Adult Population Education 03 medical and health sciences Clinical Research 2.3 Psychological Behavioral and Social Science Humans Cognitive Dysfunction Effects of sleep deprivation on cognitive performance Risk factor education Aged Inflammation 030505 public health business.industry Interleukin-6 Prevention Psychology and Cognitive Sciences Brain Disorders Good Health and Well Being business Mind and Body Regular Articles Blood sampling |
| Zdroj: | Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, vol 53, iss 1 |
| Popis: | BACKGROUND: Childhood abuse is a risk factor for the development of cognitive deficits in adulthood, a relation that is likely mediated by stress-sensitive psychological and physiological indicators. PURPOSE: To evaluate whether the link between exposure to childhood abuse and cognitive function in middle adulthood is mediated by interleukin-6 (IL-6), metabolic risk, and depressive mood symptoms. METHODS: Participants were 770 adults aged 40–65 recruited from the community, who completed the following: (i) a questionnaire assessing exposure to abuse prior to age 18, (ii) a phone interview assessing current depressive mood symptoms, and (iii) a home visit that included blood sampling for evaluation of IL-6 and assessment of metabolic risk indices. A follow-up telephone assessment evaluating cognitive function was completed by 555 of the participants. Structural equation modeling was used to test study hypotheses. RESULTS: Childhood abuse predicted higher levels of IL-6, depressive mood symptoms, and metabolic risk scores (p < .05). The relation between childhood abuse and poorer cognitive performance was mediated by IL-6 (p = .046) and depressive mood symptoms (p = .023), but not metabolic risk. IL-6 and depressive mood symptoms significantly mediated the relation between childhood abuse and adult cognitive function. CONCLUSIONS: Exposure to early abuse conveys enduring physiological and psychological effects, which may contribute to cognitive deficits that are evident by middle adulthood. Increased vulnerability for cognitive decline among adults with a history of early trauma and the mediating roles of IL-6 and depressive mood symptoms point to the potential value of interventions that address inflammation or depression, singly or together, to prevent cognitive decline in this at-risk population. |
| Databáze: | OpenAIRE |
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