Design, synthesis, and modelling study of new 1,2,3‐triazole/chalcone hybrids with antiproliferative action as epidermal growth factor receptor inhibitors

Autor:	Mohamed T.‐E. Maghraby, Ola I. A. Salem, Bahaa G. M. Youssif, Mahmoud M. Sheha
Rok vydání:	2022
Předmět:	Pharmacology Drug Discovery Organic Chemistry Molecular Medicine Biochemistry
Zdroj:	Chemical Biology & Drug Design. 101:749-759
ISSN:	1747-0285 1747-0277
DOI:	10.1111/cbdd.14178
Popis:	A novel series of 1,2,3-triazole/chalcone hybrids 6a-n was designed and synthesized using a molecular hybridization approach to develop a new cytotoxic agent capable of targeting epidermal growth factor receptor (EGFR) and/or BRAF. The antiproliferative effect of the novel hybrids was investigated against four cancer cells using doxorubicin as a reference. Hybrids 6a, 6d, 6f-h, and 6n have the highest antiproliferative activity (IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04bef2017024b0cbb6a8dad4b0b999f4 https://doi.org/10.1111/cbdd.14178 Zobrazit plný text záznamu