Spray freeze-drying as a solution to continuous manufacturing of pharmaceutical products in bulk
| Autor: | Antonello Barresi, Roberto Pisano, Merve B. Adali, Gianluca Boccardo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Process (engineering)
media_common.quotation_subject Bioengineering 02 engineering and technology lcsh:Chemical technology 030226 pharmacology & pharmacy Spray freeze-drying lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine Downstream (manufacturing) Freezing Chemical Engineering (miscellaneous) Pharmaceutical engineering lcsh:TP1-1185 Quality (business) Process engineering Throughput (business) Pharmaceutical industry media_common business.industry Process Chemistry and Technology Continuous manufacturing 021001 nanoscience & nanotechnology Atomization lcsh:QD1-999 Pharmaceutical manufacturing Pharmaceuticals 0210 nano-technology business |
| Zdroj: | Processes, Vol 8, Iss 709, p 709 (2020) |
| Popis: | Pharmaceutical manufacturing is evolving from traditional batch processes to continuous ones. The new global competition focused on throughput and quality of drug products is certainly the driving force behind this transition which, thus, represents the new challenge of pharmaceutical manufacturing and hence of lyophilization as a downstream operation. In this direction, the present review deals with the most recent technologies, based on spray freeze-drying, that can achieve this objective. It provides a comprehensive overview of the physics behind this process and of the most recent equipment design. |
| Databáze: | OpenAIRE |
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