Exploring Abstract Semantic Associations in the Frontotemporal Dementia Spectrum in a Dutch Population
| Autor: | Elise G.P. Dopper, Harro Seelaar, E Visch-Brink, E. van den Berg, Janne M. Papma, Jackie M. Poos, Yolande A.L. Pijnenburg, J. C. van Swieten, Sanne Franzen, J. van Hemmen, Djaina Satoer, Lize C. Jiskoot, Willem S. Eikelboom |
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| Přispěvatelé: | Neurology, Neurosurgery, Amsterdam Neuroscience - Neurodegeneration |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Language and language disorders Neuropsychological Tests Assessment Audiology AcademicSubjects/SCI02190 050105 experimental psychology Learning and memory Primary progressive aphasia 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being Aphasia medicine Humans Semantic memory Dementia 0501 psychology and cognitive sciences Neuropsychological assessment Language medicine.diagnostic_test AcademicSubjects/SCI01870 business.industry 05 social sciences Neuropsychology General Medicine medicine.disease Semantics Psychiatry and Mental health Clinical Psychology Aphasia Primary Progressive Neuropsychology and Physiological Psychology Frontotemporal Dementia Dutch Population Original Empirical Article medicine.symptom business 030217 neurology & neurosurgery Frontotemporal dementia |
| Zdroj: | Archives of Clinical Neuropsychology Archives of Clinical Neuropsychology, 37(1), 104-116. Elsevier Poos, J M, van den Berg, E, Visch-Brink, E, Eikelboom, W S, Franzen, S, van Hemmen, J, Pijnenburg, Y A L, Satoer, D, Dopper, E G P, van Swieten, J C, Papma, J M, Seelaar, H & Jiskoot, L C 2022, ' Exploring Abstract Semantic Associations in the Frontotemporal Dementia Spectrum in a Dutch Population ', Archives of Clinical Neuropsychology, vol. 37, no. 1, pp. 104-116 . https://doi.org/10.1093/arclin/acab022 Archives of Clinical Neuropsychology, 37(1), 104-116. Elsevier BV |
| ISSN: | 1873-5843 0887-6177 |
| DOI: | 10.1093/arclin/acab022 |
| Popis: | Objective To investigate the differential ability of the “Test Relaties Abstracte Concepten” (TRACE), a Dutch test for abstract semantic knowledge, in frontotemporal dementia (FTD). Methods The TRACE was administered in patients with behavioral variant FTD (bvFTD; n = 16), nonfluent variant (nfvPPA; n = 10), logopenic variant (lvPPA; n = 10), and semantic variant primary progressive aphasia (svPPA; n = 9), and controls (n = 59). We examined group differences, performed correlational analyses with other neuropsychological tests and investigated discriminative ability. We compared the TRACE with a semantic association test for concrete stimuli (SAT). Results All patient groups, except nfvPPA, performed worse on the TRACE than controls (p 0.6), whereas in svPPA the concrete task correlated (ρ ≥ 0.75) with language tests. Patients with bvFTD, nfvPPA and lvPPA performed lower on the TRACE than the SAT (p Discussion We demonstrated impaired abstract semantic knowledge in patients with bvFTD, lvPPA, and svPPA, but not nfvPPA, with svPPA patients performing worse than the other subtypes. The TRACE was a good classifier between each patient group versus controls and between svPPA versus other patient groups. This highlights the value of incorporating semantic tests with abstract stimuli into standard neuropsychological assessment for early differential diagnosis of FTD subtypes. |
| Databáze: | OpenAIRE |
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