Growth Retardation in Childhood Leukemia and Lymphoma
| Autor: | Kanehiro Hasuo, Kouhei Akazawa, Toshiro Kuroiwa, Yasufumi Okabe, Hideko Tasaka, Eiichi Ishii, Shin-ichi Yamada, Kohji Ueda, Takeshi Kai |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Pituitary gland Myeloid Adolescent Childhood leukemia Central nervous system Gastroenterology Central Nervous System Diseases Pituitary Gland Anterior Internal medicine medicine Humans Child Growth Disorders business.industry Lymphoma Non-Hodgkin Infant Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Magnetic Resonance Imaging Body Height Hormones Growth hormone secretion Lymphoma Leukemia Myeloid Acute Leukemia medicine.anatomical_structure Endocrinology Oncology Child Preschool Growth Hormone Pediatrics Perinatology and Child Health Female business Hormone |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 14:236-240 |
| ISSN: | 1077-4114 |
| Popis: | We studied the growth of 89 patients who were long-term survivors of childhood leukemia and lymphoma. Eight patients with CNS relapse had a greater decrease in height standard deviation score (SDS) after the relapse than 81 patients without CNS relapse (p less than 0.0001). Two patients who received cranial irradiation when they were younger than 2 years of age demonstrated a marked decrease in height SDS more than 3.0 SD. Five patients appeared to have a decline in height SDS before their CNS relapse. There were no apparent changes in the weight of patients with or without CNS relapse. In endocrine studies, all eight patients with CNS relapse failed to show the normal growth hormone (GH) response to arginine, GH-releasing factor, and glucagon-propranolol tests, while spontaneous GH secretion during sleep was normal. Magnetic resonance imaging (MRI) revealed small pituitary glands in seven patients with CNS relapse. These findings suggest that in leukemia and lymphoma patients with CNS relapse, GH secretion is impaired at the hypothalamic level, resulting in a secondary atrophy of the pituitary gland. The MRI together with selected endocrinologic tests may help to clarify the mechanism of growth impairment in such patients. A decline in height SDS in each patient may be a useful marker for predicting a CNS relapse in a child with leukemia or lymphoma. |
| Databáze: | OpenAIRE |
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