Hepatitis G Virus Infection in Amerindians and Other Venezuelan High-Risk Groups
| Autor: | Linda Blitz, Howard A. Fields, Yury Khudyakov, Mian-E. Cong, Flor H. Pujol, Simon Beker, Marisol Devesa, Carmen L. Loureiro, Freya Capriles, Ferdinando Liprandi |
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| Rok vydání: | 1998 |
| Předmět: |
Microbiology (medical)
Hepatitis Viral Human Molecular Sequence Data Population Polymerase Chain Reaction Virus Flaviviridae Renal Dialysis Virology medicine Humans Cloning Molecular education Phylogeny Polymorphism Single-Stranded Conformational Hepatitis education.field_of_study Base Sequence biology Sequence Analysis RNA Indians South American virus diseases Single-strand conformation polymorphism Hepatitis C Venezuela biology.organism_classification medicine.disease Hepatitis E digestive system diseases RNA Viral Viral disease Polymorphism Restriction Fragment Length |
| Zdroj: | Journal of Clinical Microbiology. 36:470-474 |
| ISSN: | 1098-660X 0095-1137 |
| Popis: | Recently, a new virus related to flaviviruses, the hepatitis G virus (HGV), or GBV-C virus, was discovered as a putative blood-borne human pathogen. HGV RNA (NS5 region) was amplified by reverse transcription-nested PCR in the sera of 6 of 64 (9%) hemodialysis patients; 2 of 80 (2.5%) West Yukpa Amerindians, a population with a high rate of HBV infection but negative for HCV infection; and 1 patient with an acute episode of non-A, non-B, non-C hepatitis (NABCH). The patterns of single-strand conformation polymorphism of the amplified products were unique among different specimens and similar on follow-up for hemodialysis patients. All patients tested remained HGV RNA positive 1 and 2 years later, without major sequence variation, except for the NABCH patient, for whom a double infection and an apparent clearance of the original dominant variant was observed after 2 years. The sequences of the NS5 amplified products demonstrated 85 to 90% identity with other reported HGV sequences. |
| Databáze: | OpenAIRE |
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