Clinical significance of microRNA-125b and its contribution to ovarian carcinogenesis
| Autor: | Ping Li, Fengxia Yang, Jin-ping Guan, Liming Wang, Ya-nan Bi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Adolescent endocrine system diseases s100a4 Bioengineering Apoptosis Carcinoma Ovarian Epithelial Applied Microbiology and Biotechnology Ovarian carcinogenesis Metastasis 03 medical and health sciences Mice Young Adult 0302 clinical medicine medicine mir-125b Animals Humans metastasis Epithelial ovarian cancer Clinical significance S100 Calcium-Binding Protein A4 Aged Ovarian Neoplasms business.industry Reverse Transcriptase Polymerase Chain Reaction General Medicine Middle Aged medicine.disease female genital diseases and pregnancy complications MicroRNAs 030104 developmental biology ovarian cancer 030220 oncology & carcinogenesis Cancer research Female Ovarian cancer business Mir 125b TP248.13-248.65 Research Article Research Paper Biotechnology |
| Zdroj: | Bioengineered, Vol 11, Iss 1, Pp 939-948 (2020) Bioengineered article-version (VoR) Version of Record |
| ISSN: | 2165-5987 2165-5979 |
| Popis: | The underlying mechanisms of recurrence and metastasis of epithelial ovarian cancer (EOC) are largely unknown. In the present study, we investigated the clinical significance of microRNA-125b (miR-125b) and its role in ovarian tumorigenesis and progression. Seventy patients of EOC and paired tissues were enrolled from 2015 to 2017. qRT-PCR was used to evaluate miR-125b expression in tumor tissues and EOC cell line. Gain-and-loss function of miR-125b was achieved to explore the changes in cell biological function. We found that miR-125b expression in EOC tissues, especially in the high-grade tissues (P Graphical abstract |
| Databáze: | OpenAIRE |
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