Neuroprotective effect of resveratrol prophylaxis on experimental retinal ischemic injury
| Autor: | Evan B. Stubbs, Cynthia L. Von Zee, Anita P. Vin, Ping Bu, Hanbo Hu, Andrew Logeman, Yougang Zhai, Jay I. Perlman |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Intraocular pressure Time Factors medicine.medical_treatment Intraperitoneal injection Resveratrol Pharmacology Neuroprotection Retina Rats Sprague-Dawley Cellular and Molecular Neuroscience chemistry.chemical_compound Retinal Diseases Stilbenes medicine Electroretinography Animals medicine.diagnostic_test business.industry Retinal Sensory Systems Rats Ophthalmology Disease Models Animal medicine.anatomical_structure Neuroprotective Agents chemistry Cytoprotection Anesthesia Reperfusion Injury sense organs business Erg Injections Intraperitoneal |
| Zdroj: | Experimental eye research. 108 |
| ISSN: | 1096-0007 |
| Popis: | The purpose of the present study was to investigate whether systemically administered resveratrol can protect against acute retinal ischemic reperfusion injury. Two groups of adult male Sprague Dawley rats (n = 6 per group) were used for this study. Resveratrol (30 mg/kg) or an equal volume of vehicle (30% Solutol HS 15 in 0.9% saline) was administered daily for 5 days via intraperitoneal injection. On the third day of treatment, retinal ischemic injury was induced by elevation of intraocular pressure for 45 min. Prior to resveratrol administration and one-week following ischemic insult, retinal function was measured by scotopic electroretinography (ERG). Retinas were harvested and morphologically analyzed one week after ischemic insult. ERG a- and b-wave amplitudes were significantly reduced following ischemic reperfusion injury. Resveratrol treatment attenuated ischemic-induced loss of retinal function. In control vehicle-treated rats, ischemic reperfusion injury elicited marked thinning of inner retinal layers. Resveratrol prophylactic treatment reduced ischemia-mediated thinning of the whole retina and in particular the inner retinal layers. Therefore, resveratrol may have therapeutic value for the management of retinal ischemic disorders. |
| Databáze: | OpenAIRE |
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