Short-Term d-Aspartic Acid Supplementation Does Not Affect Serum Biomarkers Associated With the Hypothalamic–Pituitary–Gonadal Axis in Male Climbers
| Autor: | Piotr Zmijewski, Konrad Witek, Blair T. Crewther, Zbigniew Obmiński, Paweł Draga |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Hypothalamo-Hypophyseal System medicine.medical_specialty Hydrocortisone Dose medicine.drug_class Pituitary-Adrenal System Medicine (miscellaneous) Hypothalamic–pituitary–gonadal axis Placebo 03 medical and health sciences 0302 clinical medicine Sex hormone-binding globulin Sex Hormone-Binding Globulin Internal medicine medicine Humans Single-Blind Method Testosterone Orthopedics and Sports Medicine Cross-Over Studies 030109 nutrition & dietetics Nutrition and Dietetics biology business.industry D-Aspartic Acid 030229 sport sciences General Medicine Luteinizing Hormone Androgen Mountaineering Sports Nutritional Physiological Phenomena Endocrinology Dietary Supplements biology.protein Luteinizing hormone business Biomarkers medicine.drug |
| Zdroj: | International Journal of Sport Nutrition and Exercise Metabolism. 29:259-264 |
| ISSN: | 1543-2742 1526-484X |
| DOI: | 10.1123/ijsnem.2018-0076 |
| Popis: | D-aspartic acid (DAA) is promoted as a testosterone (T) enhancing supplement by mechanisms involving the hypothalamic–pituitary–gonadal (HPG) axis. Here, we investigated the short-term effects of DAA on serum biomarkers of the HPG-axis in male climbers. Using a single-blinded, placebo-controlled design, 16 climbers were randomly assigned to either a DAA (3 g/day) or placebo (3 g/day) supplement for 2 weeks. The reverse treatment commenced after a 2-week washout, with all conditions administered in a balanced manner. The subjects maintained their normal weekly training across this study. Serum samples taken before and after each treatment were analyzed for T, luteinizing hormone, sex hormone binding globulin, and cortisol (C), and free T was calculated (cFT). The DAA supplement did not significantly affect serum T, cFT, and luteinizing hormone levels. Only a main effect of time on sex hormone binding globulin (6.8% increase) and C (13.6% decrease) emerged (p p > .46). Additional measures of physical function and serum hematology also failed to respond to DAA. In summary, a daily dose of DAA during a short training period did not influence T and selected indicators of the HPG-axis in male climbers. Other parameters linked to athletic performance and health status were also unaffected. Our findings support evidence showing that DAA (including DAA-blended supplements) at either recommended or higher dosages does not afford any ergogenic benefits for athletic males. |
| Databáze: | OpenAIRE |
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